The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression

Tumor cell-microenvironment interactions generate heterogeneity and promote progression. Here, Ma et al. show that the E3 ligase SIAH2 degrades NRF1 in response to hypoxia to enhance pro-tumor metabolic and environmental effects, whereas NRF1 stabilization sensitizes tumor cells to apoptosis.

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Autores principales: Biao Ma, Hongcheng Cheng, Chenglong Mu, Guangfeng Geng, Tian Zhao, Qian Luo, Kaili Ma, Rui Chang, Qiangqiang Liu, Ruize Gao, Junli Nie, Jiaying Xie, Jinxue Han, Linbo Chen, Gui Ma, Yushan Zhu, Quan Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/173fa5f435844b7ba1b18793ebce9ece
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spelling oai:doaj.org-article:173fa5f435844b7ba1b18793ebce9ece2021-12-02T14:35:49ZThe SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression10.1038/s41467-019-08618-y2041-1723https://doaj.org/article/173fa5f435844b7ba1b18793ebce9ece2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08618-yhttps://doaj.org/toc/2041-1723Tumor cell-microenvironment interactions generate heterogeneity and promote progression. Here, Ma et al. show that the E3 ligase SIAH2 degrades NRF1 in response to hypoxia to enhance pro-tumor metabolic and environmental effects, whereas NRF1 stabilization sensitizes tumor cells to apoptosis.Biao MaHongcheng ChengChenglong MuGuangfeng GengTian ZhaoQian LuoKaili MaRui ChangQiangqiang LiuRuize GaoJunli NieJiaying XieJinxue HanLinbo ChenGui MaYushan ZhuQuan ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Biao Ma
Hongcheng Cheng
Chenglong Mu
Guangfeng Geng
Tian Zhao
Qian Luo
Kaili Ma
Rui Chang
Qiangqiang Liu
Ruize Gao
Junli Nie
Jiaying Xie
Jinxue Han
Linbo Chen
Gui Ma
Yushan Zhu
Quan Chen
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
description Tumor cell-microenvironment interactions generate heterogeneity and promote progression. Here, Ma et al. show that the E3 ligase SIAH2 degrades NRF1 in response to hypoxia to enhance pro-tumor metabolic and environmental effects, whereas NRF1 stabilization sensitizes tumor cells to apoptosis.
format article
author Biao Ma
Hongcheng Cheng
Chenglong Mu
Guangfeng Geng
Tian Zhao
Qian Luo
Kaili Ma
Rui Chang
Qiangqiang Liu
Ruize Gao
Junli Nie
Jiaying Xie
Jinxue Han
Linbo Chen
Gui Ma
Yushan Zhu
Quan Chen
author_facet Biao Ma
Hongcheng Cheng
Chenglong Mu
Guangfeng Geng
Tian Zhao
Qian Luo
Kaili Ma
Rui Chang
Qiangqiang Liu
Ruize Gao
Junli Nie
Jiaying Xie
Jinxue Han
Linbo Chen
Gui Ma
Yushan Zhu
Quan Chen
author_sort Biao Ma
title The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
title_short The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
title_full The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
title_fullStr The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
title_full_unstemmed The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
title_sort siah2-nrf1 axis spatially regulates tumor microenvironment remodeling for tumor progression
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/173fa5f435844b7ba1b18793ebce9ece
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