Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice

Abstract Gut microbiota regulate the neurodevelopmental processes and brain functions through the regulation of the microbiota–gut interaction and gut–brain communication. Buspirone, an agonist for serotonin 5-HT1A receptors, is used for the treatment of anxiety/depression. Therefore, to understand...

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Autores principales:	Jeon-Kyung Kim, Sang-Kap Han, Min-Kyung Joo, Dong-Hyun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17456cd6195c4a41b191879db53c1545
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spelling	oai:doaj.org-article:17456cd6195c4a41b191879db53c15452021-12-02T13:17:41ZBuspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice10.1038/s41598-021-85681-w2045-2322https://doaj.org/article/17456cd6195c4a41b191879db53c15452021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85681-whttps://doaj.org/toc/2045-2322Abstract Gut microbiota regulate the neurodevelopmental processes and brain functions through the regulation of the microbiota–gut interaction and gut–brain communication. Buspirone, an agonist for serotonin 5-HT1A receptors, is used for the treatment of anxiety/depression. Therefore, to understand the gut microbiota-mediated mechanism of buspirone on anxiety/depression, we examined its effect on the immobilization stress (IS) or Escherichia coli K1 (EC)-induced anxiety/depression in mice. Oral or intraperitoneal administration of buspirone significantly suppressed stressor-induced anxiety/depression-like behaviors in the elevated plus maze, light/dark transition, tail suspension, and forced swimming tasks. Their treatments also reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon. Buspirone treatments partially restored IS- or EC-induced gut microbiota perturbation such as β-diversity to those of normal control mice: they reduced the IS- or EC-induced gut Proteobacteria population. In particular, the anxiolytic activity of buspirone was positively correlated with the populations of Bacteroides and PAC001066_g in EC- or IS-exposed mice, while the populations of Lachnospiraceae, KE159660_g, LLKB_g, Helicobacter, and PAC001228_g were negatively correlated. The anti-depressant effect of buspirone was positively correlated with the Roseburia population. The fecal microbiota transplantations from buspirone-treated mice with IS-induced anxiety/depression or normal control mice suppressed IS-induced anxiety/depression-like behaviors and reduced hippocampal NF-κB+/Iba1+ and colonic NF-κB+/CD11c+ cell populations in the transplanted mice. Furthermore, they modified IS-induced perturbation of gut microbiota composition, particularly Proteobacteria, in the transplanted mice. In conclusion, buspirone alleviates IS as well as EC-induced anxiety/depression and colitis. It also suppresses associated neuroinflammation and modulates gut microbiota. Future studies can help to explain the relationship, if any, in the central and peripheral effects of buspirone.Jeon-Kyung KimSang-Kap HanMin-Kyung JooDong-Hyun KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeon-Kyung Kim Sang-Kap Han Min-Kyung Joo Dong-Hyun Kim Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice
description	Abstract Gut microbiota regulate the neurodevelopmental processes and brain functions through the regulation of the microbiota–gut interaction and gut–brain communication. Buspirone, an agonist for serotonin 5-HT1A receptors, is used for the treatment of anxiety/depression. Therefore, to understand the gut microbiota-mediated mechanism of buspirone on anxiety/depression, we examined its effect on the immobilization stress (IS) or Escherichia coli K1 (EC)-induced anxiety/depression in mice. Oral or intraperitoneal administration of buspirone significantly suppressed stressor-induced anxiety/depression-like behaviors in the elevated plus maze, light/dark transition, tail suspension, and forced swimming tasks. Their treatments also reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon. Buspirone treatments partially restored IS- or EC-induced gut microbiota perturbation such as β-diversity to those of normal control mice: they reduced the IS- or EC-induced gut Proteobacteria population. In particular, the anxiolytic activity of buspirone was positively correlated with the populations of Bacteroides and PAC001066_g in EC- or IS-exposed mice, while the populations of Lachnospiraceae, KE159660_g, LLKB_g, Helicobacter, and PAC001228_g were negatively correlated. The anti-depressant effect of buspirone was positively correlated with the Roseburia population. The fecal microbiota transplantations from buspirone-treated mice with IS-induced anxiety/depression or normal control mice suppressed IS-induced anxiety/depression-like behaviors and reduced hippocampal NF-κB+/Iba1+ and colonic NF-κB+/CD11c+ cell populations in the transplanted mice. Furthermore, they modified IS-induced perturbation of gut microbiota composition, particularly Proteobacteria, in the transplanted mice. In conclusion, buspirone alleviates IS as well as EC-induced anxiety/depression and colitis. It also suppresses associated neuroinflammation and modulates gut microbiota. Future studies can help to explain the relationship, if any, in the central and peripheral effects of buspirone.
format	article
author	Jeon-Kyung Kim Sang-Kap Han Min-Kyung Joo Dong-Hyun Kim
author_facet	Jeon-Kyung Kim Sang-Kap Han Min-Kyung Joo Dong-Hyun Kim
author_sort	Jeon-Kyung Kim
title	Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice
title_short	Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice
title_full	Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice
title_fullStr	Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice
title_full_unstemmed	Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice
title_sort	buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17456cd6195c4a41b191879db53c1545
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Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice

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