Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors

There is limited knowledge of markers to identify various waves of murine embryonic hematopoiesis. Here, the authors show that the expression of toll-like receptor 2 (TLR2) on E7.5 c-kit+ cells marks the emergence of erythro-myeloid progenitor precursors and that the Tlr2 locus is active in E8.5 pre...

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Autores principales:	Jana Balounová, Iva Šplíchalová, Martina Dobešová, Michal Kolář, Karel Fišer, Jan Procházka, Radislav Sedlacek, Andrea Jurisicova, Hoon-ki Sung, Vladimír Kořínek, Meritxell Alberich-Jorda, Isabelle Godin, Dominik Filipp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17467f1f4d9e41dd9240272eae57c26a
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spelling	oai:doaj.org-article:17467f1f4d9e41dd9240272eae57c26a2021-12-02T17:01:44ZToll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors10.1038/s41467-019-13150-02041-1723https://doaj.org/article/17467f1f4d9e41dd9240272eae57c26a2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13150-0https://doaj.org/toc/2041-1723There is limited knowledge of markers to identify various waves of murine embryonic hematopoiesis. Here, the authors show that the expression of toll-like receptor 2 (TLR2) on E7.5 c-kit+ cells marks the emergence of erythro-myeloid progenitor precursors and that the Tlr2 locus is active in E8.5 precursors of adult HSCs.Jana BalounováIva ŠplíchalováMartina DobešováMichal KolářKarel FišerJan ProcházkaRadislav SedlacekAndrea JurisicovaHoon-ki SungVladimír KořínekMeritxell Alberich-JordaIsabelle GodinDominik FilippNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jana Balounová Iva Šplíchalová Martina Dobešová Michal Kolář Karel Fišer Jan Procházka Radislav Sedlacek Andrea Jurisicova Hoon-ki Sung Vladimír Kořínek Meritxell Alberich-Jorda Isabelle Godin Dominik Filipp Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
description	There is limited knowledge of markers to identify various waves of murine embryonic hematopoiesis. Here, the authors show that the expression of toll-like receptor 2 (TLR2) on E7.5 c-kit+ cells marks the emergence of erythro-myeloid progenitor precursors and that the Tlr2 locus is active in E8.5 precursors of adult HSCs.
format	article
author	Jana Balounová Iva Šplíchalová Martina Dobešová Michal Kolář Karel Fišer Jan Procházka Radislav Sedlacek Andrea Jurisicova Hoon-ki Sung Vladimír Kořínek Meritxell Alberich-Jorda Isabelle Godin Dominik Filipp
author_facet	Jana Balounová Iva Šplíchalová Martina Dobešová Michal Kolář Karel Fišer Jan Procházka Radislav Sedlacek Andrea Jurisicova Hoon-ki Sung Vladimír Kořínek Meritxell Alberich-Jorda Isabelle Godin Dominik Filipp
author_sort	Jana Balounová
title	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
title_short	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
title_full	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
title_fullStr	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
title_full_unstemmed	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
title_sort	toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/17467f1f4d9e41dd9240272eae57c26a
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Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors

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