Thermolabile drug storage in an ambulatory setting

Abstract More thermolabile drugs are becoming available, and in most cases, these medications are dispensed to ambulatory patients. However, there is no regulation once medications are dispensed to patients and little is known with regard to what happens during transport and home storage. Previous s...

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Autores principales:	Fernando do Pazo-Oubiña, Bartomeu Alorda-Ladaria, Ana Gomez-Lobon, Bàrbara Boyeras-Vallespir, María Margalida Santandreu-Estelrich, Clara Martorell-Puigserver, María Gomez-Zamora, Pere Ventayol-Bosch, Olga Delgado-Sanchez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1749a2a11700472b8a3351a1476abff0
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spelling	oai:doaj.org-article:1749a2a11700472b8a3351a1476abff02021-12-02T11:39:20ZThermolabile drug storage in an ambulatory setting10.1038/s41598-021-85413-02045-2322https://doaj.org/article/1749a2a11700472b8a3351a1476abff02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85413-0https://doaj.org/toc/2045-2322Abstract More thermolabile drugs are becoming available, and in most cases, these medications are dispensed to ambulatory patients. However, there is no regulation once medications are dispensed to patients and little is known with regard to what happens during transport and home storage. Previous studies suggest that these drugs are improperly stored. The present study was designed to determine the storage conditions of thermolabile drugs once they are dispensed to the patient in the Hospital Pharmacy Department. This is a prospective observational study to assess the temperature profile of 7 thermolabile drugs once they are dispensed to ambulatory patients at a tertiary care hospital. A data logger was added to the medication packaging. Temperature was considered inappropriate if one of the following circumstances were met: any temperature record less than or equal to 0 °C or over 25 °C; temperatures between 0–2 or 8–25 °C for a continuous period over 30 min. The time series of temperature measurements obtained from each data logger were analyzed as statistically independent variables. The data shown did not undergo any statistical treatment and must be considered directly related to thermal measurements. One hundred and fourteen patients were included and 107 patients were available for the analysis. On the whole, a mean of 50.6 days (SD 18.3) were measured and the mean temperature was 6.88 °C (SD 2.93). Three data loggers (2.8%) maintained all the measurements between 2 and 8 °C with less than 3 continuous data (< 30 min) out of this range but no data over 25 °C or below or equal to 0 °C. 28 (26.2%) data loggers had at least one measurement below zero, 1 data logger had a measurement greater than 25 °C and 75 (70.1%) were between 0 and 2 °C and/or between 8 and 25 °C for more than 30 min. In conclusion, once dispensed to patients, most thermolabile drugs are improperly stored. Future studies should focus on clinical consequences and possible solutions.Fernando do Pazo-OubiñaBartomeu Alorda-LadariaAna Gomez-LobonBàrbara Boyeras-VallespirMaría Margalida Santandreu-EstelrichClara Martorell-PuigserverMaría Gomez-ZamoraPere Ventayol-BoschOlga Delgado-SanchezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fernando do Pazo-Oubiña Bartomeu Alorda-Ladaria Ana Gomez-Lobon Bàrbara Boyeras-Vallespir María Margalida Santandreu-Estelrich Clara Martorell-Puigserver María Gomez-Zamora Pere Ventayol-Bosch Olga Delgado-Sanchez Thermolabile drug storage in an ambulatory setting
description	Abstract More thermolabile drugs are becoming available, and in most cases, these medications are dispensed to ambulatory patients. However, there is no regulation once medications are dispensed to patients and little is known with regard to what happens during transport and home storage. Previous studies suggest that these drugs are improperly stored. The present study was designed to determine the storage conditions of thermolabile drugs once they are dispensed to the patient in the Hospital Pharmacy Department. This is a prospective observational study to assess the temperature profile of 7 thermolabile drugs once they are dispensed to ambulatory patients at a tertiary care hospital. A data logger was added to the medication packaging. Temperature was considered inappropriate if one of the following circumstances were met: any temperature record less than or equal to 0 °C or over 25 °C; temperatures between 0–2 or 8–25 °C for a continuous period over 30 min. The time series of temperature measurements obtained from each data logger were analyzed as statistically independent variables. The data shown did not undergo any statistical treatment and must be considered directly related to thermal measurements. One hundred and fourteen patients were included and 107 patients were available for the analysis. On the whole, a mean of 50.6 days (SD 18.3) were measured and the mean temperature was 6.88 °C (SD 2.93). Three data loggers (2.8%) maintained all the measurements between 2 and 8 °C with less than 3 continuous data (< 30 min) out of this range but no data over 25 °C or below or equal to 0 °C. 28 (26.2%) data loggers had at least one measurement below zero, 1 data logger had a measurement greater than 25 °C and 75 (70.1%) were between 0 and 2 °C and/or between 8 and 25 °C for more than 30 min. In conclusion, once dispensed to patients, most thermolabile drugs are improperly stored. Future studies should focus on clinical consequences and possible solutions.
format	article
author	Fernando do Pazo-Oubiña Bartomeu Alorda-Ladaria Ana Gomez-Lobon Bàrbara Boyeras-Vallespir María Margalida Santandreu-Estelrich Clara Martorell-Puigserver María Gomez-Zamora Pere Ventayol-Bosch Olga Delgado-Sanchez
author_facet	Fernando do Pazo-Oubiña Bartomeu Alorda-Ladaria Ana Gomez-Lobon Bàrbara Boyeras-Vallespir María Margalida Santandreu-Estelrich Clara Martorell-Puigserver María Gomez-Zamora Pere Ventayol-Bosch Olga Delgado-Sanchez
author_sort	Fernando do Pazo-Oubiña
title	Thermolabile drug storage in an ambulatory setting
title_short	Thermolabile drug storage in an ambulatory setting
title_full	Thermolabile drug storage in an ambulatory setting
title_fullStr	Thermolabile drug storage in an ambulatory setting
title_full_unstemmed	Thermolabile drug storage in an ambulatory setting
title_sort	thermolabile drug storage in an ambulatory setting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1749a2a11700472b8a3351a1476abff0
work_keys_str_mv	AT fernandodopazooubina thermolabiledrugstorageinanambulatorysetting AT bartomeualordaladaria thermolabiledrugstorageinanambulatorysetting AT anagomezlobon thermolabiledrugstorageinanambulatorysetting AT barbaraboyerasvallespir thermolabiledrugstorageinanambulatorysetting AT mariamargalidasantandreuestelrich thermolabiledrugstorageinanambulatorysetting AT claramartorellpuigserver thermolabiledrugstorageinanambulatorysetting AT mariagomezzamora thermolabiledrugstorageinanambulatorysetting AT pereventayolbosch thermolabiledrugstorageinanambulatorysetting AT olgadelgadosanchez thermolabiledrugstorageinanambulatorysetting
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Thermolabile drug storage in an ambulatory setting

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