Nanobodies as novel agents for disease diagnosis and therapy

Christina G Siontorou Department of Industrial Management and Technology, University of Piraeus, Piraeus, Greece Abstract: The discovery of naturally occurring, heavy-chain only antibodies in Camelidae, and their further development into small recombinant nanobodies, presents attractive alternatives...

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Autor principal:	Siontorou CG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1749be6960c9450bbf09a95555703e60
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spelling	oai:doaj.org-article:1749be6960c9450bbf09a95555703e602021-12-02T11:07:29ZNanobodies as novel agents for disease diagnosis and therapy1176-91141178-2013https://doaj.org/article/1749be6960c9450bbf09a95555703e602013-11-01T00:00:00Zhttp://www.dovepress.com/nanobodies-as-novel-agents-for-disease-diagnosis-and-therapy-a14870https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Christina G Siontorou Department of Industrial Management and Technology, University of Piraeus, Piraeus, Greece Abstract: The discovery of naturally occurring, heavy-chain only antibodies in Camelidae, and their further development into small recombinant nanobodies, presents attractive alternatives in drug delivery and imaging. Easily expressed in microorganisms and amenable to engineering, nanobody derivatives are soluble, stable, versatile, and have unique refolding capacities, reduced aggregation tendencies, and high-target binding capabilities. This review outlines the current state of the art in nanobodies, focusing on their structural features and properties, production, technology, and the potential for modulating immune functions and for targeting tumors, toxins, and microbes. Keywords: heavy chain antibodies, nanobodies, antibody expression, molecular display, formattingSiontorou CGDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4215-4227 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Siontorou CG Nanobodies as novel agents for disease diagnosis and therapy
description	Christina G Siontorou Department of Industrial Management and Technology, University of Piraeus, Piraeus, Greece Abstract: The discovery of naturally occurring, heavy-chain only antibodies in Camelidae, and their further development into small recombinant nanobodies, presents attractive alternatives in drug delivery and imaging. Easily expressed in microorganisms and amenable to engineering, nanobody derivatives are soluble, stable, versatile, and have unique refolding capacities, reduced aggregation tendencies, and high-target binding capabilities. This review outlines the current state of the art in nanobodies, focusing on their structural features and properties, production, technology, and the potential for modulating immune functions and for targeting tumors, toxins, and microbes. Keywords: heavy chain antibodies, nanobodies, antibody expression, molecular display, formatting
format	article
author	Siontorou CG
author_facet	Siontorou CG
author_sort	Siontorou CG
title	Nanobodies as novel agents for disease diagnosis and therapy
title_short	Nanobodies as novel agents for disease diagnosis and therapy
title_full	Nanobodies as novel agents for disease diagnosis and therapy
title_fullStr	Nanobodies as novel agents for disease diagnosis and therapy
title_full_unstemmed	Nanobodies as novel agents for disease diagnosis and therapy
title_sort	nanobodies as novel agents for disease diagnosis and therapy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/1749be6960c9450bbf09a95555703e60
work_keys_str_mv	AT siontoroucg nanobodiesasnovelagentsfordiseasediagnosisandtherapy
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Nanobodies as novel agents for disease diagnosis and therapy

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