Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice

Cancer stem cells (CSC) have been shown as the origin for therapeutic resistance and patient relapse. Here, the authors show that targeting Arf1-mediated lipid metabolism in CSC induces cell death but also an immunogenic anti-cancer response.

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Autores principales:	Guohao Wang, Junji Xu, Jiangsha Zhao, Weiqin Yin, Dayong Liu, WanJun Chen, Steven X. Hou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/174cbfcf447b4a919eb206138ce1043c
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spelling	oai:doaj.org-article:174cbfcf447b4a919eb206138ce1043c2021-12-02T14:42:29ZArf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice10.1038/s41467-019-14046-92041-1723https://doaj.org/article/174cbfcf447b4a919eb206138ce1043c2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14046-9https://doaj.org/toc/2041-1723Cancer stem cells (CSC) have been shown as the origin for therapeutic resistance and patient relapse. Here, the authors show that targeting Arf1-mediated lipid metabolism in CSC induces cell death but also an immunogenic anti-cancer response.Guohao WangJunji XuJiangsha ZhaoWeiqin YinDayong LiuWanJun ChenSteven X. HouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guohao Wang Junji Xu Jiangsha Zhao Weiqin Yin Dayong Liu WanJun Chen Steven X. Hou Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
description	Cancer stem cells (CSC) have been shown as the origin for therapeutic resistance and patient relapse. Here, the authors show that targeting Arf1-mediated lipid metabolism in CSC induces cell death but also an immunogenic anti-cancer response.
format	article
author	Guohao Wang Junji Xu Jiangsha Zhao Weiqin Yin Dayong Liu WanJun Chen Steven X. Hou
author_facet	Guohao Wang Junji Xu Jiangsha Zhao Weiqin Yin Dayong Liu WanJun Chen Steven X. Hou
author_sort	Guohao Wang
title	Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
title_short	Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
title_full	Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
title_fullStr	Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
title_full_unstemmed	Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
title_sort	arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/174cbfcf447b4a919eb206138ce1043c
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Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice

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