Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.

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Detalles Bibliográficos
Autores principales: Muhammad M. Mohiuddin, Avneesh K. Singh, Philip C. Corcoran, Marvin L. Thomas III, Tannia Clark, Billeta G. Lewis, Robert F. Hoyt, Michael Eckhaus, Richard N. Pierson III, Aaron J. Belli, Eckhard Wolf, Nikolai Klymiuk, Carol Phelps, Keith A. Reimann, David Ayares, Keith A. Horvath
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/1753025819414c9294cfec9508216a69
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Descripción
Sumario:Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.

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