Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.

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Autores principales:	Muhammad M. Mohiuddin, Avneesh K. Singh, Philip C. Corcoran, Marvin L. Thomas III, Tannia Clark, Billeta G. Lewis, Robert F. Hoyt, Michael Eckhaus, Richard N. Pierson III, Aaron J. Belli, Eckhard Wolf, Nikolai Klymiuk, Carol Phelps, Keith A. Reimann, David Ayares, Keith A. Horvath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1753025819414c9294cfec9508216a69
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spelling	oai:doaj.org-article:1753025819414c9294cfec9508216a692021-12-02T14:38:55ZChimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft10.1038/ncomms111382041-1723https://doaj.org/article/1753025819414c9294cfec9508216a692016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11138https://doaj.org/toc/2041-1723Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.Muhammad M. MohiuddinAvneesh K. SinghPhilip C. CorcoranMarvin L. Thomas IIITannia ClarkBilleta G. LewisRobert F. HoytMichael EckhausRichard N. Pierson IIIAaron J. BelliEckhard WolfNikolai KlymiukCarol PhelpsKeith A. ReimannDavid AyaresKeith A. HorvathNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muhammad M. Mohiuddin Avneesh K. Singh Philip C. Corcoran Marvin L. Thomas III Tannia Clark Billeta G. Lewis Robert F. Hoyt Michael Eckhaus Richard N. Pierson III Aaron J. Belli Eckhard Wolf Nikolai Klymiuk Carol Phelps Keith A. Reimann David Ayares Keith A. Horvath Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
description	Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.
format	article
author	Muhammad M. Mohiuddin Avneesh K. Singh Philip C. Corcoran Marvin L. Thomas III Tannia Clark Billeta G. Lewis Robert F. Hoyt Michael Eckhaus Richard N. Pierson III Aaron J. Belli Eckhard Wolf Nikolai Klymiuk Carol Phelps Keith A. Reimann David Ayares Keith A. Horvath
author_facet	Muhammad M. Mohiuddin Avneesh K. Singh Philip C. Corcoran Marvin L. Thomas III Tannia Clark Billeta G. Lewis Robert F. Hoyt Michael Eckhaus Richard N. Pierson III Aaron J. Belli Eckhard Wolf Nikolai Klymiuk Carol Phelps Keith A. Reimann David Ayares Keith A. Horvath
author_sort	Muhammad M. Mohiuddin
title	Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
title_short	Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
title_full	Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
title_fullStr	Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
title_full_unstemmed	Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
title_sort	chimeric 2c10r4 anti-cd40 antibody therapy is critical for long-term survival of gtko.hcd46.htbm pig-to-primate cardiac xenograft
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1753025819414c9294cfec9508216a69
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Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

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