Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography

Abstract Swept-source optical coherence tomography (SS-OCT) is an attractive high-speed imaging technique for retinal angiography. However, conventional swept lasers vary the cavity length of the laser mechanically to tune the output wavelength. This causes sweep-timing jitter and hence low phase st...

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Autores principales:	Kwan Seob Park, Eunwoo Park, Hwidon Lee, Hyun-Ji Lee, Sang-Won Lee, Tae Joong Eom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17543b0d266a4b00abe464c12943b172
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spelling	oai:doaj.org-article:17543b0d266a4b00abe464c12943b1722021-12-02T16:45:54ZPhase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography10.1038/s41598-021-95982-92045-2322https://doaj.org/article/17543b0d266a4b00abe464c12943b1722021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95982-9https://doaj.org/toc/2045-2322Abstract Swept-source optical coherence tomography (SS-OCT) is an attractive high-speed imaging technique for retinal angiography. However, conventional swept lasers vary the cavity length of the laser mechanically to tune the output wavelength. This causes sweep-timing jitter and hence low phase stability in OCT angiography. Here, we improve an earlier phase-stabilized, akinetic, SS-OCT angiography (OCTA) method by introducing coherent averaging. We develop an active mode-locking (AML) laser as a high phase-stable akinetic swept source for the OCTA system. The phase stability of the improved system was analyzed, and the effects of coherent averaging were validated using a retina phantom. The effectiveness of the coherent averaging method was further confirmed by comparing coherently and conventionally averaged en face images of human retinal vasculature for their contrast-to-noise ratio, signal-to-noise ratio, and vasculature connectivity. The contrast-to-noise ratio was approximately 1.3 times larger when applying the coherent averaging method in the human retinal experiment. Our coherent averaging method with the high phase-stability AML laser source for OCTA provides a valuable tool for studying healthy and diseased retinas.Kwan Seob ParkEunwoo ParkHwidon LeeHyun-Ji LeeSang-Won LeeTae Joong EomNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kwan Seob Park Eunwoo Park Hwidon Lee Hyun-Ji Lee Sang-Won Lee Tae Joong Eom Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography
description	Abstract Swept-source optical coherence tomography (SS-OCT) is an attractive high-speed imaging technique for retinal angiography. However, conventional swept lasers vary the cavity length of the laser mechanically to tune the output wavelength. This causes sweep-timing jitter and hence low phase stability in OCT angiography. Here, we improve an earlier phase-stabilized, akinetic, SS-OCT angiography (OCTA) method by introducing coherent averaging. We develop an active mode-locking (AML) laser as a high phase-stable akinetic swept source for the OCTA system. The phase stability of the improved system was analyzed, and the effects of coherent averaging were validated using a retina phantom. The effectiveness of the coherent averaging method was further confirmed by comparing coherently and conventionally averaged en face images of human retinal vasculature for their contrast-to-noise ratio, signal-to-noise ratio, and vasculature connectivity. The contrast-to-noise ratio was approximately 1.3 times larger when applying the coherent averaging method in the human retinal experiment. Our coherent averaging method with the high phase-stability AML laser source for OCTA provides a valuable tool for studying healthy and diseased retinas.
format	article
author	Kwan Seob Park Eunwoo Park Hwidon Lee Hyun-Ji Lee Sang-Won Lee Tae Joong Eom
author_facet	Kwan Seob Park Eunwoo Park Hwidon Lee Hyun-Ji Lee Sang-Won Lee Tae Joong Eom
author_sort	Kwan Seob Park
title	Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography
title_short	Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography
title_full	Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography
title_fullStr	Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography
title_full_unstemmed	Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography
title_sort	phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17543b0d266a4b00abe464c12943b172
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Phase stable swept-source optical coherence tomography with active mode-locking laser for contrast enhancements of retinal angiography

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