Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery

Abstract This study aimed to examine the effect of antibiotic prophylaxis (AP) given within 30 compared to 30–60 min before skin incision on the incidence of infectious morbidity after cesarean delivery (CD). A retrospective cohort study was conducted at a single institution on data between 2014 and...

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Autores principales:	Hadas Rubin, Eyal Rom, Malak Wattad, Khadeje Seh, Natanel Levy, Ayellet Jehassi, Shabtai Romano, Raed Salim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17570d43572948df9f7d62383683aa6e
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spelling	oai:doaj.org-article:17570d43572948df9f7d62383683aa6e2021-12-02T14:27:53ZEffectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery10.1038/s41598-021-87846-z2045-2322https://doaj.org/article/17570d43572948df9f7d62383683aa6e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87846-zhttps://doaj.org/toc/2045-2322Abstract This study aimed to examine the effect of antibiotic prophylaxis (AP) given within 30 compared to 30–60 min before skin incision on the incidence of infectious morbidity after cesarean delivery (CD). A retrospective cohort study was conducted at a single institution on data between 2014 and 2018. Women who delivered by CD were divided into two groups according to AP timing before skin incision: group 1 within 30 min, and group 2 from 30 to 60 min. The primary outcome was the incidence of any infectious morbidity. Overall, 2989 women were eligible: 2791 in group 1 and 198 in group 2. The primary composite outcome occurred in 125 women (4.48%) in group 1 and 8 women (4.04%) in group 2 (OR, 1.11; 95% CI 0.54–2.31; P = 0.77). The rate of surgical site infection only, was 1.08% in group 1 and 0.51% in group 2 (OR, 2.13; 95% CI 0.29–15.70; P = 0.72). The incidence was comparable between the groups in a separate sub-analysis restricted to laboring CDs and obese women. The rate of infectious morbidity was similar among women who received AP within 30 min and from 30 to 60 min before skin incision.Hadas RubinEyal RomMalak WattadKhadeje SehNatanel LevyAyellet JehassiShabtai RomanoRaed SalimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hadas Rubin Eyal Rom Malak Wattad Khadeje Seh Natanel Levy Ayellet Jehassi Shabtai Romano Raed Salim Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
description	Abstract This study aimed to examine the effect of antibiotic prophylaxis (AP) given within 30 compared to 30–60 min before skin incision on the incidence of infectious morbidity after cesarean delivery (CD). A retrospective cohort study was conducted at a single institution on data between 2014 and 2018. Women who delivered by CD were divided into two groups according to AP timing before skin incision: group 1 within 30 min, and group 2 from 30 to 60 min. The primary outcome was the incidence of any infectious morbidity. Overall, 2989 women were eligible: 2791 in group 1 and 198 in group 2. The primary composite outcome occurred in 125 women (4.48%) in group 1 and 8 women (4.04%) in group 2 (OR, 1.11; 95% CI 0.54–2.31; P = 0.77). The rate of surgical site infection only, was 1.08% in group 1 and 0.51% in group 2 (OR, 2.13; 95% CI 0.29–15.70; P = 0.72). The incidence was comparable between the groups in a separate sub-analysis restricted to laboring CDs and obese women. The rate of infectious morbidity was similar among women who received AP within 30 min and from 30 to 60 min before skin incision.
format	article
author	Hadas Rubin Eyal Rom Malak Wattad Khadeje Seh Natanel Levy Ayellet Jehassi Shabtai Romano Raed Salim
author_facet	Hadas Rubin Eyal Rom Malak Wattad Khadeje Seh Natanel Levy Ayellet Jehassi Shabtai Romano Raed Salim
author_sort	Hadas Rubin
title	Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
title_short	Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
title_full	Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
title_fullStr	Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
title_full_unstemmed	Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
title_sort	effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17570d43572948df9f7d62383683aa6e
work_keys_str_mv	AT hadasrubin effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery AT eyalrom effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery AT malakwattad effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery AT khadejeseh effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery AT natanellevy effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery AT ayelletjehassi effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery AT shabtairomano effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery AT raedsalim effectivenessofantimicrobialprophylaxisat30versus60minbeforecesareandelivery
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Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery

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