Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut

Diener, Hoge et al. show that a third of mice exhibit tolerance to a high dose of the β-lactam antibiotic cefoperazone, independent of antibiotic treatment duration or dietary phytochemical amendment. They find that non-responder microbiota upregulates antimicrobial tolerance genes and downregulates...

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Autores principales:	Christian Diener, Anna C. H. Hoge, Sean M. Kearney, Ulrike Kusebauch, Sushmita Patwardhan, Robert L. Moritz, Susan E. Erdman, Sean M. Gibbons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1758da1e4c754e25902bac750a5689f9
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spelling	oai:doaj.org-article:1758da1e4c754e25902bac750a5689f92021-12-02T13:34:50ZNon-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut10.1038/s42003-021-01841-82399-3642https://doaj.org/article/1758da1e4c754e25902bac750a5689f92021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01841-8https://doaj.org/toc/2399-3642Diener, Hoge et al. show that a third of mice exhibit tolerance to a high dose of the β-lactam antibiotic cefoperazone, independent of antibiotic treatment duration or dietary phytochemical amendment. They find that non-responder microbiota upregulates antimicrobial tolerance genes and downregulates central metabolism without altering community composition or diversity, providing insights into the mechanisms of community-wide antibiotic tolerance.Christian DienerAnna C. H. HogeSean M. KearneyUlrike KusebauchSushmita PatwardhanRobert L. MoritzSusan E. ErdmanSean M. GibbonsNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Christian Diener Anna C. H. Hoge Sean M. Kearney Ulrike Kusebauch Sushmita Patwardhan Robert L. Moritz Susan E. Erdman Sean M. Gibbons Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut
description	Diener, Hoge et al. show that a third of mice exhibit tolerance to a high dose of the β-lactam antibiotic cefoperazone, independent of antibiotic treatment duration or dietary phytochemical amendment. They find that non-responder microbiota upregulates antimicrobial tolerance genes and downregulates central metabolism without altering community composition or diversity, providing insights into the mechanisms of community-wide antibiotic tolerance.
format	article
author	Christian Diener Anna C. H. Hoge Sean M. Kearney Ulrike Kusebauch Sushmita Patwardhan Robert L. Moritz Susan E. Erdman Sean M. Gibbons
author_facet	Christian Diener Anna C. H. Hoge Sean M. Kearney Ulrike Kusebauch Sushmita Patwardhan Robert L. Moritz Susan E. Erdman Sean M. Gibbons
author_sort	Christian Diener
title	Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut
title_short	Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut
title_full	Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut
title_fullStr	Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut
title_full_unstemmed	Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut
title_sort	non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1758da1e4c754e25902bac750a5689f9
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Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut

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