Human rhinovirus serotypes induces different immune responses

Abstract Background Different species of human rhinovirus (HRV) can induce varied antiviral and inflammatory responses in human blood macrophages and lower airway epithelium. Although human nasal epithelial cells (HNECs) are a primary infection route of HRV, differences between major and minor group...

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Autores principales:	Ji Heui Kim, Jung Yeon Jang, Yong Ju Jang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Human rhinovirus Interferon IL-8 TLR3 MDA5 NF-κB Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/17672ea947ab48aab3f7b2bd1409692c
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spelling	oai:doaj.org-article:17672ea947ab48aab3f7b2bd1409692c2021-11-28T12:03:03ZHuman rhinovirus serotypes induces different immune responses10.1186/s12985-021-01701-11743-422Xhttps://doaj.org/article/17672ea947ab48aab3f7b2bd1409692c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01701-1https://doaj.org/toc/1743-422XAbstract Background Different species of human rhinovirus (HRV) can induce varied antiviral and inflammatory responses in human blood macrophages and lower airway epithelium. Although human nasal epithelial cells (HNECs) are a primary infection route of HRV, differences between major and minor groups of HRV in the upper airway epithelium have not been studied in detail. In this study, we investigated viral replications and immune responses of major and minor groups of HRV in the HNECs. Methods Viral replication, immune responses of IFN-β, IFN-λ, proinflammatory cytokines, and viral receptors, and mRNA expression of transcription factors of HRV16 (major group) and HRV1B (minor group) in the HNECs were assessed. Results Compared with HRV16, HRV1B replicated more actively without excessive cell death and produced higher IFN-β, IFN-λ1/3, CXCL10, IL-6, IL-8, and IL-18 levels. Furthermore, low-density lipoprotein receptor (LDLR), TLR3, MDA5, NF-κB, STAT1, and STAT2 mRNA levels increased in HRV1B-infected HNECs. Conclusion HRV1B induces a stronger antiviral and inflammatory response from cell entry to downstream signaling compared with HRV16.Ji Heui KimJung Yeon JangYong Ju JangBMCarticleHuman rhinovirusInterferonIL-8TLR3MDA5NF-κBInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Human rhinovirus Interferon IL-8 TLR3 MDA5 NF-κB Infectious and parasitic diseases RC109-216
spellingShingle	Human rhinovirus Interferon IL-8 TLR3 MDA5 NF-κB Infectious and parasitic diseases RC109-216 Ji Heui Kim Jung Yeon Jang Yong Ju Jang Human rhinovirus serotypes induces different immune responses
description	Abstract Background Different species of human rhinovirus (HRV) can induce varied antiviral and inflammatory responses in human blood macrophages and lower airway epithelium. Although human nasal epithelial cells (HNECs) are a primary infection route of HRV, differences between major and minor groups of HRV in the upper airway epithelium have not been studied in detail. In this study, we investigated viral replications and immune responses of major and minor groups of HRV in the HNECs. Methods Viral replication, immune responses of IFN-β, IFN-λ, proinflammatory cytokines, and viral receptors, and mRNA expression of transcription factors of HRV16 (major group) and HRV1B (minor group) in the HNECs were assessed. Results Compared with HRV16, HRV1B replicated more actively without excessive cell death and produced higher IFN-β, IFN-λ1/3, CXCL10, IL-6, IL-8, and IL-18 levels. Furthermore, low-density lipoprotein receptor (LDLR), TLR3, MDA5, NF-κB, STAT1, and STAT2 mRNA levels increased in HRV1B-infected HNECs. Conclusion HRV1B induces a stronger antiviral and inflammatory response from cell entry to downstream signaling compared with HRV16.
format	article
author	Ji Heui Kim Jung Yeon Jang Yong Ju Jang
author_facet	Ji Heui Kim Jung Yeon Jang Yong Ju Jang
author_sort	Ji Heui Kim
title	Human rhinovirus serotypes induces different immune responses
title_short	Human rhinovirus serotypes induces different immune responses
title_full	Human rhinovirus serotypes induces different immune responses
title_fullStr	Human rhinovirus serotypes induces different immune responses
title_full_unstemmed	Human rhinovirus serotypes induces different immune responses
title_sort	human rhinovirus serotypes induces different immune responses
publisher	BMC
publishDate	2021
url	https://doaj.org/article/17672ea947ab48aab3f7b2bd1409692c
work_keys_str_mv	AT jiheuikim humanrhinovirusserotypesinducesdifferentimmuneresponses AT jungyeonjang humanrhinovirusserotypesinducesdifferentimmuneresponses AT yongjujang humanrhinovirusserotypesinducesdifferentimmuneresponses
_version_	1718408243504480256

Human rhinovirus serotypes induces different immune responses

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