The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol

Background: The efficacy of interlimb-coordinated training on gait and upper limb functional improvement remains unclear. The latest published randomized controlled trials have supported the potential benefits of interlimb-coordinated training to enhance gait function. Upper limb functional recovery...

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Autores principales:	Wai-Leung Ambrose Lo, Dandan Chen, Jiangli Zhao, Yan Leng, Ruihao Bian, Wenzhu Huang, Yahui Liang, Yu-Rong Mao, Dong-Feng Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arm cycling interlimb coordinated limb linkage gait stroke EEG Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1768e3b35c2b4ff1bb0fe96f3f59556f
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spelling	oai:doaj.org-article:1768e3b35c2b4ff1bb0fe96f3f59556f2021-11-25T16:58:27ZThe Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol10.3390/brainsci111114952076-3425https://doaj.org/article/1768e3b35c2b4ff1bb0fe96f3f59556f2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1495https://doaj.org/toc/2076-3425Background: The efficacy of interlimb-coordinated training on gait and upper limb functional improvement remains unclear. The latest published randomized controlled trials have supported the potential benefits of interlimb-coordinated training to enhance gait function. Upper limb functional recovery may also benefit from interlimb-coordinated training since most everyday activities require the coordinated use of both hands to complete a task. This study investigates the efficacy of interlimb-coordinated training on gait and upper limb functional recovery over a short-medium term period. Methods: A total of 226 acute stroke patients will be recruited from four centres over four years. Patients will be randomly allocated to either conventional therapy or conventional therapy plus interlimb-coordinated training. Outcomes will be recorded at baseline, after 2 weeks of intervention, and at 3- and 6-months post-intervention. Gait speed is the primary outcome measure. Secondary outcome measures include Fugl–Meyer Assessment of Motor Recovery, Berg Balance Scale, Timed Up and Go test, Action Research Arm Test, electroencephalography, and magnetic resonance imaging. Conclusion: The results of this trial will provide an in-depth understanding of the efficacy of early interlimb-coordinated intervention on gait and upper functional rehabilitation and how it may relate to the neural plasticity process.Wai-Leung Ambrose LoDandan ChenJiangli ZhaoYan LengRuihao BianWenzhu HuangYahui LiangYu-Rong MaoDong-Feng HuangMDPI AGarticlearm cyclinginterlimb coordinatedlimb linkagegaitstrokeEEGNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1495, p 1495 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arm cycling interlimb coordinated limb linkage gait stroke EEG Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	arm cycling interlimb coordinated limb linkage gait stroke EEG Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Wai-Leung Ambrose Lo Dandan Chen Jiangli Zhao Yan Leng Ruihao Bian Wenzhu Huang Yahui Liang Yu-Rong Mao Dong-Feng Huang The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol
description	Background: The efficacy of interlimb-coordinated training on gait and upper limb functional improvement remains unclear. The latest published randomized controlled trials have supported the potential benefits of interlimb-coordinated training to enhance gait function. Upper limb functional recovery may also benefit from interlimb-coordinated training since most everyday activities require the coordinated use of both hands to complete a task. This study investigates the efficacy of interlimb-coordinated training on gait and upper limb functional recovery over a short-medium term period. Methods: A total of 226 acute stroke patients will be recruited from four centres over four years. Patients will be randomly allocated to either conventional therapy or conventional therapy plus interlimb-coordinated training. Outcomes will be recorded at baseline, after 2 weeks of intervention, and at 3- and 6-months post-intervention. Gait speed is the primary outcome measure. Secondary outcome measures include Fugl–Meyer Assessment of Motor Recovery, Berg Balance Scale, Timed Up and Go test, Action Research Arm Test, electroencephalography, and magnetic resonance imaging. Conclusion: The results of this trial will provide an in-depth understanding of the efficacy of early interlimb-coordinated intervention on gait and upper functional rehabilitation and how it may relate to the neural plasticity process.
format	article
author	Wai-Leung Ambrose Lo Dandan Chen Jiangli Zhao Yan Leng Ruihao Bian Wenzhu Huang Yahui Liang Yu-Rong Mao Dong-Feng Huang
author_facet	Wai-Leung Ambrose Lo Dandan Chen Jiangli Zhao Yan Leng Ruihao Bian Wenzhu Huang Yahui Liang Yu-Rong Mao Dong-Feng Huang
author_sort	Wai-Leung Ambrose Lo
title	The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol
title_short	The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol
title_full	The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol
title_fullStr	The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol
title_full_unstemmed	The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol
title_sort	efficacy of interlimb-coordinated intervention on gait and motor function recovery in patients with acute stroke: a multi-center randomized controlled trial study protocol
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1768e3b35c2b4ff1bb0fe96f3f59556f
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The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol

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