Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure

Abstract In neurophysiology, nonhuman primates represent an important model for studying the brain. Typically, monkeys are moved from their home cage to an experimental room daily, where they sit in a primate chair and interact with electronic devices. Refining this procedure would make the research...

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Autores principales: Stefano Sacchetti, Francesco Ceccarelli, Lorenzo Ferrucci, Danilo Benozzo, Emiliano Brunamonti, Simon Nougaret, Aldo Genovesio
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/176b64bb2fbd4dd3812f96daa19f25e6
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spelling oai:doaj.org-article:176b64bb2fbd4dd3812f96daa19f25e62021-12-02T14:16:58ZMacaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure10.1038/s41598-021-82021-w2045-2322https://doaj.org/article/176b64bb2fbd4dd3812f96daa19f25e62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82021-whttps://doaj.org/toc/2045-2322Abstract In neurophysiology, nonhuman primates represent an important model for studying the brain. Typically, monkeys are moved from their home cage to an experimental room daily, where they sit in a primate chair and interact with electronic devices. Refining this procedure would make the researchers’ work easier and improve the animals’ welfare. To address this issue, we used home-cage training to train two macaque monkeys in a non-match-to-goal task, where each trial required a switch from the choice made in the previous trial to obtain a reward. The monkeys were tested in two versions of the task, one in which they acted as the agent in every trial and one in which some trials were completed by a “ghost agent”. We evaluated their involvement in terms of their performance and their interaction with the apparatus. Both monkeys were able to maintain a constant involvement in the task with good, stable performance within sessions in both versions of the task. Our study confirms the feasibility of home-cage training and demonstrates that even with challenging tasks, monkeys can complete a large number of trials at a high performance level, which is a prerequisite for electrophysiological studies of monkey behavior.Stefano SacchettiFrancesco CeccarelliLorenzo FerrucciDanilo BenozzoEmiliano BrunamontiSimon NougaretAldo GenovesioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Stefano Sacchetti
Francesco Ceccarelli
Lorenzo Ferrucci
Danilo Benozzo
Emiliano Brunamonti
Simon Nougaret
Aldo Genovesio
Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
description Abstract In neurophysiology, nonhuman primates represent an important model for studying the brain. Typically, monkeys are moved from their home cage to an experimental room daily, where they sit in a primate chair and interact with electronic devices. Refining this procedure would make the researchers’ work easier and improve the animals’ welfare. To address this issue, we used home-cage training to train two macaque monkeys in a non-match-to-goal task, where each trial required a switch from the choice made in the previous trial to obtain a reward. The monkeys were tested in two versions of the task, one in which they acted as the agent in every trial and one in which some trials were completed by a “ghost agent”. We evaluated their involvement in terms of their performance and their interaction with the apparatus. Both monkeys were able to maintain a constant involvement in the task with good, stable performance within sessions in both versions of the task. Our study confirms the feasibility of home-cage training and demonstrates that even with challenging tasks, monkeys can complete a large number of trials at a high performance level, which is a prerequisite for electrophysiological studies of monkey behavior.
format article
author Stefano Sacchetti
Francesco Ceccarelli
Lorenzo Ferrucci
Danilo Benozzo
Emiliano Brunamonti
Simon Nougaret
Aldo Genovesio
author_facet Stefano Sacchetti
Francesco Ceccarelli
Lorenzo Ferrucci
Danilo Benozzo
Emiliano Brunamonti
Simon Nougaret
Aldo Genovesio
author_sort Stefano Sacchetti
title Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_short Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_full Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_fullStr Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_full_unstemmed Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_sort macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/176b64bb2fbd4dd3812f96daa19f25e6
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