Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure

Abstract In neurophysiology, nonhuman primates represent an important model for studying the brain. Typically, monkeys are moved from their home cage to an experimental room daily, where they sit in a primate chair and interact with electronic devices. Refining this procedure would make the research...

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Autores principales:	Stefano Sacchetti, Francesco Ceccarelli, Lorenzo Ferrucci, Danilo Benozzo, Emiliano Brunamonti, Simon Nougaret, Aldo Genovesio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/176b64bb2fbd4dd3812f96daa19f25e6
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spelling	oai:doaj.org-article:176b64bb2fbd4dd3812f96daa19f25e62021-12-02T14:16:58ZMacaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure10.1038/s41598-021-82021-w2045-2322https://doaj.org/article/176b64bb2fbd4dd3812f96daa19f25e62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82021-whttps://doaj.org/toc/2045-2322Abstract In neurophysiology, nonhuman primates represent an important model for studying the brain. Typically, monkeys are moved from their home cage to an experimental room daily, where they sit in a primate chair and interact with electronic devices. Refining this procedure would make the researchers’ work easier and improve the animals’ welfare. To address this issue, we used home-cage training to train two macaque monkeys in a non-match-to-goal task, where each trial required a switch from the choice made in the previous trial to obtain a reward. The monkeys were tested in two versions of the task, one in which they acted as the agent in every trial and one in which some trials were completed by a “ghost agent”. We evaluated their involvement in terms of their performance and their interaction with the apparatus. Both monkeys were able to maintain a constant involvement in the task with good, stable performance within sessions in both versions of the task. Our study confirms the feasibility of home-cage training and demonstrates that even with challenging tasks, monkeys can complete a large number of trials at a high performance level, which is a prerequisite for electrophysiological studies of monkey behavior.Stefano SacchettiFrancesco CeccarelliLorenzo FerrucciDanilo BenozzoEmiliano BrunamontiSimon NougaretAldo GenovesioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Sacchetti Francesco Ceccarelli Lorenzo Ferrucci Danilo Benozzo Emiliano Brunamonti Simon Nougaret Aldo Genovesio Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
description	Abstract In neurophysiology, nonhuman primates represent an important model for studying the brain. Typically, monkeys are moved from their home cage to an experimental room daily, where they sit in a primate chair and interact with electronic devices. Refining this procedure would make the researchers’ work easier and improve the animals’ welfare. To address this issue, we used home-cage training to train two macaque monkeys in a non-match-to-goal task, where each trial required a switch from the choice made in the previous trial to obtain a reward. The monkeys were tested in two versions of the task, one in which they acted as the agent in every trial and one in which some trials were completed by a “ghost agent”. We evaluated their involvement in terms of their performance and their interaction with the apparatus. Both monkeys were able to maintain a constant involvement in the task with good, stable performance within sessions in both versions of the task. Our study confirms the feasibility of home-cage training and demonstrates that even with challenging tasks, monkeys can complete a large number of trials at a high performance level, which is a prerequisite for electrophysiological studies of monkey behavior.
format	article
author	Stefano Sacchetti Francesco Ceccarelli Lorenzo Ferrucci Danilo Benozzo Emiliano Brunamonti Simon Nougaret Aldo Genovesio
author_facet	Stefano Sacchetti Francesco Ceccarelli Lorenzo Ferrucci Danilo Benozzo Emiliano Brunamonti Simon Nougaret Aldo Genovesio
author_sort	Stefano Sacchetti
title	Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_short	Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_full	Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_fullStr	Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_full_unstemmed	Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
title_sort	macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/176b64bb2fbd4dd3812f96daa19f25e6
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Macaque monkeys learn and perform a non-match-to-goal task using an automated home cage training procedure

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