Multi-cellular logistics of collective cell migration.

During development, the formation of biological networks (such as organs and neuronal networks) is controlled by multicellular transportation phenomena based on cell migration. In multi-cellular systems, cellular locomotion is restricted by physical interactions with other cells in a crowded space,...

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Autores principales:	Masataka Yamao, Honda Naoki, Shin Ishii
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/176b8967f52b4fde87419b9e65415dd9
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spelling	oai:doaj.org-article:176b8967f52b4fde87419b9e65415dd92021-11-18T07:31:47ZMulti-cellular logistics of collective cell migration.1932-620310.1371/journal.pone.0027950https://doaj.org/article/176b8967f52b4fde87419b9e65415dd92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22205934/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203During development, the formation of biological networks (such as organs and neuronal networks) is controlled by multicellular transportation phenomena based on cell migration. In multi-cellular systems, cellular locomotion is restricted by physical interactions with other cells in a crowded space, similar to passengers pushing others out of their way on a packed train. The motion of individual cells is intrinsically stochastic and may be viewed as a type of random walk. However, this walk takes place in a noisy environment because the cell interacts with its randomly moving neighbors. Despite this randomness and complexity, development is highly orchestrated and precisely regulated, following genetic (and even epigenetic) blueprints. Although individual cell migration has long been studied, the manner in which stochasticity affects multi-cellular transportation within the precisely controlled process of development remains largely unknown. To explore the general principles underlying multicellular migration, we focus on the migration of neural crest cells, which migrate collectively and form streams. We introduce a mechanical model of multi-cellular migration. Simulations based on the model show that the migration mode depends on the relative strengths of the noise from migratory and non-migratory cells. Strong noise from migratory cells and weak noise from surrounding cells causes "collective migration," whereas strong noise from non-migratory cells causes "dispersive migration." Moreover, our theoretical analyses reveal that migratory cells attract each other over long distances, even without direct mechanical contacts. This effective interaction depends on the stochasticity of the migratory and non-migratory cells. On the basis of these findings, we propose that stochastic behavior at the single-cell level works effectively and precisely to achieve collective migration in multi-cellular systems.Masataka YamaoHonda NaokiShin IshiiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e27950 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masataka Yamao Honda Naoki Shin Ishii Multi-cellular logistics of collective cell migration.
description	During development, the formation of biological networks (such as organs and neuronal networks) is controlled by multicellular transportation phenomena based on cell migration. In multi-cellular systems, cellular locomotion is restricted by physical interactions with other cells in a crowded space, similar to passengers pushing others out of their way on a packed train. The motion of individual cells is intrinsically stochastic and may be viewed as a type of random walk. However, this walk takes place in a noisy environment because the cell interacts with its randomly moving neighbors. Despite this randomness and complexity, development is highly orchestrated and precisely regulated, following genetic (and even epigenetic) blueprints. Although individual cell migration has long been studied, the manner in which stochasticity affects multi-cellular transportation within the precisely controlled process of development remains largely unknown. To explore the general principles underlying multicellular migration, we focus on the migration of neural crest cells, which migrate collectively and form streams. We introduce a mechanical model of multi-cellular migration. Simulations based on the model show that the migration mode depends on the relative strengths of the noise from migratory and non-migratory cells. Strong noise from migratory cells and weak noise from surrounding cells causes "collective migration," whereas strong noise from non-migratory cells causes "dispersive migration." Moreover, our theoretical analyses reveal that migratory cells attract each other over long distances, even without direct mechanical contacts. This effective interaction depends on the stochasticity of the migratory and non-migratory cells. On the basis of these findings, we propose that stochastic behavior at the single-cell level works effectively and precisely to achieve collective migration in multi-cellular systems.
format	article
author	Masataka Yamao Honda Naoki Shin Ishii
author_facet	Masataka Yamao Honda Naoki Shin Ishii
author_sort	Masataka Yamao
title	Multi-cellular logistics of collective cell migration.
title_short	Multi-cellular logistics of collective cell migration.
title_full	Multi-cellular logistics of collective cell migration.
title_fullStr	Multi-cellular logistics of collective cell migration.
title_full_unstemmed	Multi-cellular logistics of collective cell migration.
title_sort	multi-cellular logistics of collective cell migration.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/176b8967f52b4fde87419b9e65415dd9
work_keys_str_mv	AT masatakayamao multicellularlogisticsofcollectivecellmigration AT hondanaoki multicellularlogisticsofcollectivecellmigration AT shinishii multicellularlogisticsofcollectivecellmigration
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Multi-cellular logistics of collective cell migration.

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