IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.

Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose tissue after cold exposure and β3-adrenoceptor...

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Autores principales:	Lingyi Li, Lei Ma, Zewei Zhao, Shiya Luo, Baoyong Gong, Jin Li, Juan Feng, Hui Zhang, Weiwei Qi, Ti Zhou, Xia Yang, Guoquan Gao, Zhonghan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/17701971be2d4b04a89d08397091c4b9
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spelling	oai:doaj.org-article:17701971be2d4b04a89d08397091c4b92021-12-02T19:54:40ZIL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.1544-91731545-788510.1371/journal.pbio.3001348https://doaj.org/article/17701971be2d4b04a89d08397091c4b92021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001348https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose tissue after cold exposure and β3-adrenoceptor agonist stimulation. IL-25 induced beige fat formation in white adipose tissue (WAT) by releasing IL-4 and IL-13 and promoting alternative activation of macrophages that regulate innervation and up-regulate tyrosine hydroxylase (TH) up-regulation to produce more catecholamine including norepinephrine (NE). Blockade of IL-4Rα or depletion of macrophages with clodronate-loaded liposomes in vivo significantly impaired the beige fat formation in WAT. Mice fed with a high-fat diet (HFD) were protected from obesity and related metabolic disorders when given IL-25 through a process that involved the uncoupling protein 1 (UCP1)-mediated thermogenesis. In conclusion, the activation of IL-25 signaling in WAT may have therapeutic potential for controlling obesity and its associated metabolic disorders.Lingyi LiLei MaZewei ZhaoShiya LuoBaoyong GongJin LiJuan FengHui ZhangWeiwei QiTi ZhouXia YangGuoquan GaoZhonghan YangPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 8, p e3001348 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lingyi Li Lei Ma Zewei Zhao Shiya Luo Baoyong Gong Jin Li Juan Feng Hui Zhang Weiwei Qi Ti Zhou Xia Yang Guoquan Gao Zhonghan Yang IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
description	Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB), increased in adipose tissue after cold exposure and β3-adrenoceptor agonist stimulation. IL-25 induced beige fat formation in white adipose tissue (WAT) by releasing IL-4 and IL-13 and promoting alternative activation of macrophages that regulate innervation and up-regulate tyrosine hydroxylase (TH) up-regulation to produce more catecholamine including norepinephrine (NE). Blockade of IL-4Rα or depletion of macrophages with clodronate-loaded liposomes in vivo significantly impaired the beige fat formation in WAT. Mice fed with a high-fat diet (HFD) were protected from obesity and related metabolic disorders when given IL-25 through a process that involved the uncoupling protein 1 (UCP1)-mediated thermogenesis. In conclusion, the activation of IL-25 signaling in WAT may have therapeutic potential for controlling obesity and its associated metabolic disorders.
format	article
author	Lingyi Li Lei Ma Zewei Zhao Shiya Luo Baoyong Gong Jin Li Juan Feng Hui Zhang Weiwei Qi Ti Zhou Xia Yang Guoquan Gao Zhonghan Yang
author_facet	Lingyi Li Lei Ma Zewei Zhao Shiya Luo Baoyong Gong Jin Li Juan Feng Hui Zhang Weiwei Qi Ti Zhou Xia Yang Guoquan Gao Zhonghan Yang
author_sort	Lingyi Li
title	IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
title_short	IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
title_full	IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
title_fullStr	IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
title_full_unstemmed	IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
title_sort	il-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/17701971be2d4b04a89d08397091c4b9
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IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.

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