Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder

Abstract Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopatho...

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Autores principales:	Flurin Cathomas, Karoline Guetter, Erich Seifritz, Federica Klaus, Stefan Kaiser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1776a6e286cd4af58010460e1f044ff1
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spelling	oai:doaj.org-article:1776a6e286cd4af58010460e1f044ff12021-12-02T15:36:13ZQuinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder10.1038/s41598-021-89335-92045-2322https://doaj.org/article/1776a6e286cd4af58010460e1f044ff12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89335-9https://doaj.org/toc/2045-2322Abstract Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathological dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid in the plasma of 19 healthy controls (HC), 45 patients with SZ and 43 patients with MDD and correlated plasma proteins with the “motivation and pleasure” dimension and cognition. After correcting for the covariates age, sex, body mass index, smoking and medication, patients with MDD showed lower kynurenine and 3-hydroxy kynurenine levels compared to HC. Quinolinic acid correlated negatively with composite cognitive score in patients with SZ, indicating that more severe cognitive impairments were associated with increased plasma levels of quinolinic acid. No correlations were found in patients with MDD. These results indicate that MDD and SZ are associated with dysregulation of the kynurenine pathway. Quinolinic acid might be specifically implicated in the pathophysiology of cognitive deficits in patients with SZ. Further studies are needed to determine whether TRYCATs are causally involved in the etiology of these neuropsychiatric disorders.Flurin CathomasKaroline GuetterErich SeifritzFederica KlausStefan KaiserNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Flurin Cathomas Karoline Guetter Erich Seifritz Federica Klaus Stefan Kaiser Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
description	Abstract Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathological dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid in the plasma of 19 healthy controls (HC), 45 patients with SZ and 43 patients with MDD and correlated plasma proteins with the “motivation and pleasure” dimension and cognition. After correcting for the covariates age, sex, body mass index, smoking and medication, patients with MDD showed lower kynurenine and 3-hydroxy kynurenine levels compared to HC. Quinolinic acid correlated negatively with composite cognitive score in patients with SZ, indicating that more severe cognitive impairments were associated with increased plasma levels of quinolinic acid. No correlations were found in patients with MDD. These results indicate that MDD and SZ are associated with dysregulation of the kynurenine pathway. Quinolinic acid might be specifically implicated in the pathophysiology of cognitive deficits in patients with SZ. Further studies are needed to determine whether TRYCATs are causally involved in the etiology of these neuropsychiatric disorders.
format	article
author	Flurin Cathomas Karoline Guetter Erich Seifritz Federica Klaus Stefan Kaiser
author_facet	Flurin Cathomas Karoline Guetter Erich Seifritz Federica Klaus Stefan Kaiser
author_sort	Flurin Cathomas
title	Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
title_short	Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
title_full	Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
title_fullStr	Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
title_full_unstemmed	Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
title_sort	quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1776a6e286cd4af58010460e1f044ff1
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Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder

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