The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome

Priya Desai, Lorin Donovan, Elizabeth Janowitz, Joon Young Kim Department of Exercise Science, Syracuse University, Syracuse, NY, USACorrespondence: Joon Young KimDepartment of Exercise Science, Syracuse University, Women’s Building 204E, 820 Comstock Ave, Syracuse, NY 13244, USATel +1 315...

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Autores principales:	Desai P, Donovan L, Janowitz E, Kim JY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	saliva inflammation type 2 diabetes biomarkers metabolic syndrome oxidative stress Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1781a75b111e423d9f99af05731c632e
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spelling	oai:doaj.org-article:1781a75b111e423d9f99af05731c632e2021-12-02T11:50:16ZThe Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome1178-7007https://doaj.org/article/1781a75b111e423d9f99af05731c632e2020-10-01T00:00:00Zhttps://www.dovepress.com/the-clinical-utility-of-salivary-biomarkers-in-the-identification-of-t-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Priya Desai, Lorin Donovan, Elizabeth Janowitz, Joon Young Kim Department of Exercise Science, Syracuse University, Syracuse, NY, USACorrespondence: Joon Young KimDepartment of Exercise Science, Syracuse University, Women’s Building 204E, 820 Comstock Ave, Syracuse, NY 13244, USATel +1 315-443-1411Fax +1 315-443-9375Email jkim291@syr.eduAbstract: Type 2 diabetes is traditionally diagnosed by the use of an oral glucose tolerance test and/or HbA1c, both of which require serum collection. Various biomarkers, which are measurable biological substances that provide clinical insight on disease state, have also been effective in the early identification and risk prediction of inflammatory diseases. Measuring biomarker concentrations has traditionally been obtained through serum collection as well. However, numerous biomarkers are detectable in saliva. Salivary analysis has more recently been introduced into research as a potential non-invasive, cost-effective diagnostic for the early identification of type 2 diabetes risk in adults and youth. Therefore, the purpose of this review was to compare 6 established inflammatory biomarkers of type 2 diabetes, in serum and saliva, and determine if similar diagnostic effectiveness is seen in saliva. A lack of standardized salivary analysis, processing, and collection accounts for errors and inconsistencies in conclusive data amongst studies. Proposing a national standardization in salivary analysis, coupled with increased data and research on the utility of saliva as a diagnostic, poses the potential for salivary analysis to be used in diagnostic settings.Keywords: saliva, inflammation, type 2 diabetes, biomarkers, metabolic syndrome, oxidative stressDesai PDonovan LJanowitz EKim JYDove Medical Pressarticlesalivainflammationtype 2 diabetesbiomarkersmetabolic syndromeoxidative stressSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3587-3599 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	saliva inflammation type 2 diabetes biomarkers metabolic syndrome oxidative stress Specialties of internal medicine RC581-951
spellingShingle	saliva inflammation type 2 diabetes biomarkers metabolic syndrome oxidative stress Specialties of internal medicine RC581-951 Desai P Donovan L Janowitz E Kim JY The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome
description	Priya Desai, Lorin Donovan, Elizabeth Janowitz, Joon Young Kim Department of Exercise Science, Syracuse University, Syracuse, NY, USACorrespondence: Joon Young KimDepartment of Exercise Science, Syracuse University, Women’s Building 204E, 820 Comstock Ave, Syracuse, NY 13244, USATel +1 315-443-1411Fax +1 315-443-9375Email jkim291@syr.eduAbstract: Type 2 diabetes is traditionally diagnosed by the use of an oral glucose tolerance test and/or HbA1c, both of which require serum collection. Various biomarkers, which are measurable biological substances that provide clinical insight on disease state, have also been effective in the early identification and risk prediction of inflammatory diseases. Measuring biomarker concentrations has traditionally been obtained through serum collection as well. However, numerous biomarkers are detectable in saliva. Salivary analysis has more recently been introduced into research as a potential non-invasive, cost-effective diagnostic for the early identification of type 2 diabetes risk in adults and youth. Therefore, the purpose of this review was to compare 6 established inflammatory biomarkers of type 2 diabetes, in serum and saliva, and determine if similar diagnostic effectiveness is seen in saliva. A lack of standardized salivary analysis, processing, and collection accounts for errors and inconsistencies in conclusive data amongst studies. Proposing a national standardization in salivary analysis, coupled with increased data and research on the utility of saliva as a diagnostic, poses the potential for salivary analysis to be used in diagnostic settings.Keywords: saliva, inflammation, type 2 diabetes, biomarkers, metabolic syndrome, oxidative stress
format	article
author	Desai P Donovan L Janowitz E Kim JY
author_facet	Desai P Donovan L Janowitz E Kim JY
author_sort	Desai P
title	The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome
title_short	The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome
title_full	The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome
title_fullStr	The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome
title_full_unstemmed	The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome
title_sort	clinical utility of salivary biomarkers in the identification of type 2 diabetes risk and metabolic syndrome
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1781a75b111e423d9f99af05731c632e
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The Clinical Utility of Salivary Biomarkers in the Identification of Type 2 Diabetes Risk and Metabolic Syndrome

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