Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats

Talal A Zari, Mesfer A Al-Thebaiti Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Purpose: The aim of this study was to investigate the effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin induced diab...

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Autores principales:	Zari TA, Al-Thebaiti MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Caralluma russeliana diabetes mellitus streptozotocin blood physiological parameters rats Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/17880ae6c39d41c08d89d8916f72b18c
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spelling	oai:doaj.org-article:17880ae6c39d41c08d89d8916f72b18c2021-12-02T02:24:40ZEffects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats1178-7007https://doaj.org/article/17880ae6c39d41c08d89d8916f72b18c2018-10-01T00:00:00Zhttps://www.dovepress.com/effects-of-caralluma-russeliana-stem-extract-on-some-physiological-par-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Talal A Zari, Mesfer A Al-Thebaiti Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Purpose: The aim of this study was to investigate the effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin induced diabetes in male Wistar rats after 8 weeks. Materials and methods: The experimental rats were randomly assigned into four groups. Rats of group 1 were normal controls. Rats of group 2 were diabetic controls. Rats of group 3 were diabetic rats treated with C. russeliana stem extract. Rats of group 4 were non-diabetic rats, subjected to C. russeliana stem extract. Results: The lowest body weight gain was noticed in diabetic rats of group 2. Serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, ALP, total bilirubin, creatinine, blood urea nitrogen (BUN) and uric acid levels were significantly elevated in diabetic rats of group 2; however, total serum protein, albumin and high-density lipoprotein cholesterol were significantly reduced in diabetic rats of group 2. Conclusion: Treatments with C. russeliana stem extract in diabetic rats revealed notable diminishing and protecting effects of physiological modifications. Therefore, this study revealed the significance of using C. russeliana stem extract as a promising remedial agent to treat diabetes and its complications. Keywords: Caralluma russeliana, diabetes, streptozotocin, weight loss, glucose, lipids, liver enzymes, kidney function, ratsZari TAAl-Thebaiti MADove Medical PressarticleCaralluma russelianadiabetes mellitusstreptozotocinbloodphysiological parametersratsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 619-631 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Caralluma russeliana diabetes mellitus streptozotocin blood physiological parameters rats Specialties of internal medicine RC581-951
spellingShingle	Caralluma russeliana diabetes mellitus streptozotocin blood physiological parameters rats Specialties of internal medicine RC581-951 Zari TA Al-Thebaiti MA Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
description	Talal A Zari, Mesfer A Al-Thebaiti Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Purpose: The aim of this study was to investigate the effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin induced diabetes in male Wistar rats after 8 weeks. Materials and methods: The experimental rats were randomly assigned into four groups. Rats of group 1 were normal controls. Rats of group 2 were diabetic controls. Rats of group 3 were diabetic rats treated with C. russeliana stem extract. Rats of group 4 were non-diabetic rats, subjected to C. russeliana stem extract. Results: The lowest body weight gain was noticed in diabetic rats of group 2. Serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, ALP, total bilirubin, creatinine, blood urea nitrogen (BUN) and uric acid levels were significantly elevated in diabetic rats of group 2; however, total serum protein, albumin and high-density lipoprotein cholesterol were significantly reduced in diabetic rats of group 2. Conclusion: Treatments with C. russeliana stem extract in diabetic rats revealed notable diminishing and protecting effects of physiological modifications. Therefore, this study revealed the significance of using C. russeliana stem extract as a promising remedial agent to treat diabetes and its complications. Keywords: Caralluma russeliana, diabetes, streptozotocin, weight loss, glucose, lipids, liver enzymes, kidney function, rats
format	article
author	Zari TA Al-Thebaiti MA
author_facet	Zari TA Al-Thebaiti MA
author_sort	Zari TA
title	Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
title_short	Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
title_full	Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
title_fullStr	Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
title_full_unstemmed	Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
title_sort	effects of caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/17880ae6c39d41c08d89d8916f72b18c
work_keys_str_mv	AT zarita effectsofcarallumarusselianastemextractonsomephysiologicalparametersinstreptozotocininduceddiabeticmalerats AT althebaitima effectsofcarallumarusselianastemextractonsomephysiologicalparametersinstreptozotocininduceddiabeticmalerats
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Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats

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