An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.

<h4>Background</h4>The apparent high number of deaths in Argentina during the 2009 pandemic led to concern that the influenza A H1N1pdm disease was different there. We report the characteristics and risk factors for influenza A H1N1pdm fatalities.<h4>Methods</h4>We identified...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ana M Balanzat, Christian Hertlein, Carlos Apezteguia, Pablo Bonvehi, Luis Cámera, Angela Gentile, Oscar Rizzo, Manuel Gómez-Carrillo, Fatima Coronado, Eduardo Azziz-Baumgartner, Pollyanna R Chávez, Marc-Alain Widdowson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1789a14ffe5f4da29b4e7816e652b062
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1789a14ffe5f4da29b4e7816e652b062
record_format	dspace
spelling	oai:doaj.org-article:1789a14ffe5f4da29b4e7816e652b0622021-11-18T07:22:50ZAn analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.1932-620310.1371/journal.pone.0033670https://doaj.org/article/1789a14ffe5f4da29b4e7816e652b0622012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22506006/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The apparent high number of deaths in Argentina during the 2009 pandemic led to concern that the influenza A H1N1pdm disease was different there. We report the characteristics and risk factors for influenza A H1N1pdm fatalities.<h4>Methods</h4>We identified laboratory-confirmed influenza A H1N1pdm fatalities occurring during June-July 2009. Physicians abstracted data on age, sex, time of onset of illness, medical history, clinical presentation at admission, laboratory, treatment, and outcomes using standardize questionnaires. We explored the characteristics of fatalities according to their age and risk group.<h4>Results</h4>Of 332 influenza A H1N1pdm fatalities, 226 (68%) were among persons aged <50 years. Acute respiratory failure was the leading cause of death. Of all cases, 249 (75%) had at least one comorbidity as defined by Advisory Committee on Immunization Practices. Obesity was reported in 32% with data and chronic pulmonary disease in 28%. Among the 40 deaths in children aged <5 years, chronic pulmonary disease (42%) and neonatal pathologies (35%) were the most common co-morbidities. Twenty (6%) fatalities were among pregnant or postpartum women of which only 47% had diagnosed co-morbidities. Only 13% of patients received antiviral treatment within 48 hours of symptom onset. None of children aged <5 years or the pregnant women received antivirals within 48 h of symptom onset. As the pandemic progressed, the time from symptom-onset to medical care and to antiviral treatment decreased significantly among case-patients who subsequently died (p<0.001).<h4>Conclusion</h4>Persons with co-morbidities, pregnant and who received antivirals late were over-represented among influenza A H1N1pdm deaths in Argentina, though timeliness of antiviral treatment improved during the pandemic.Ana M BalanzatChristian HertleinCarlos ApezteguiaPablo BonvehiLuis CámeraAngela GentileOscar RizzoManuel Gómez-CarrilloFatima CoronadoEduardo Azziz-BaumgartnerPollyanna R ChávezMarc-Alain WiddowsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e33670 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana M Balanzat Christian Hertlein Carlos Apezteguia Pablo Bonvehi Luis Cámera Angela Gentile Oscar Rizzo Manuel Gómez-Carrillo Fatima Coronado Eduardo Azziz-Baumgartner Pollyanna R Chávez Marc-Alain Widdowson An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.
description	<h4>Background</h4>The apparent high number of deaths in Argentina during the 2009 pandemic led to concern that the influenza A H1N1pdm disease was different there. We report the characteristics and risk factors for influenza A H1N1pdm fatalities.<h4>Methods</h4>We identified laboratory-confirmed influenza A H1N1pdm fatalities occurring during June-July 2009. Physicians abstracted data on age, sex, time of onset of illness, medical history, clinical presentation at admission, laboratory, treatment, and outcomes using standardize questionnaires. We explored the characteristics of fatalities according to their age and risk group.<h4>Results</h4>Of 332 influenza A H1N1pdm fatalities, 226 (68%) were among persons aged <50 years. Acute respiratory failure was the leading cause of death. Of all cases, 249 (75%) had at least one comorbidity as defined by Advisory Committee on Immunization Practices. Obesity was reported in 32% with data and chronic pulmonary disease in 28%. Among the 40 deaths in children aged <5 years, chronic pulmonary disease (42%) and neonatal pathologies (35%) were the most common co-morbidities. Twenty (6%) fatalities were among pregnant or postpartum women of which only 47% had diagnosed co-morbidities. Only 13% of patients received antiviral treatment within 48 hours of symptom onset. None of children aged <5 years or the pregnant women received antivirals within 48 h of symptom onset. As the pandemic progressed, the time from symptom-onset to medical care and to antiviral treatment decreased significantly among case-patients who subsequently died (p<0.001).<h4>Conclusion</h4>Persons with co-morbidities, pregnant and who received antivirals late were over-represented among influenza A H1N1pdm deaths in Argentina, though timeliness of antiviral treatment improved during the pandemic.
format	article
author	Ana M Balanzat Christian Hertlein Carlos Apezteguia Pablo Bonvehi Luis Cámera Angela Gentile Oscar Rizzo Manuel Gómez-Carrillo Fatima Coronado Eduardo Azziz-Baumgartner Pollyanna R Chávez Marc-Alain Widdowson
author_facet	Ana M Balanzat Christian Hertlein Carlos Apezteguia Pablo Bonvehi Luis Cámera Angela Gentile Oscar Rizzo Manuel Gómez-Carrillo Fatima Coronado Eduardo Azziz-Baumgartner Pollyanna R Chávez Marc-Alain Widdowson
author_sort	Ana M Balanzat
title	An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.
title_short	An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.
title_full	An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.
title_fullStr	An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.
title_full_unstemmed	An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.
title_sort	analysis of 332 fatalities infected with pandemic 2009 influenza a (h1n1) in argentina.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1789a14ffe5f4da29b4e7816e652b062
work_keys_str_mv	AT anambalanzat ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT christianhertlein ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT carlosapezteguia ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT pablobonvehi ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT luiscamera ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT angelagentile ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT oscarrizzo ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT manuelgomezcarrillo ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT fatimacoronado ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT eduardoazzizbaumgartner ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT pollyannarchavez ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT marcalainwiddowson ananalysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT anambalanzat analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT christianhertlein analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT carlosapezteguia analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT pablobonvehi analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT luiscamera analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT angelagentile analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT oscarrizzo analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT manuelgomezcarrillo analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT fatimacoronado analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT eduardoazzizbaumgartner analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT pollyannarchavez analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina AT marcalainwiddowson analysisof332fatalitiesinfectedwithpandemic2009influenzaah1n1inargentina
_version_	1718423520226050048

An analysis of 332 fatalities infected with pandemic 2009 influenza A (H1N1) in Argentina.

Ejemplares similares