Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition

Context: Hyperuricemia is defined when the plasma uric acid concentration is above 416 μmol/L (7 mg/dl) in male adults, or 357 μmol/L (6 mg/dl) in female adults. However, there are no explicit criteria yet for children.Objective: It is necessary to set up reference intervals for the uric acid level...

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Autores principales:	Chengjun Dai, Chaoban Wang, Fangqin Xia, Zishuo Liu, Yiqi Mo, Xiaoou Shan, Yonghai Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	uric acid children reference interval Southeast China body mass index Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/178a167fcbc74549bcaf724ae8187aed
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spelling	oai:doaj.org-article:178a167fcbc74549bcaf724ae8187aed2021-11-10T07:21:15ZAge and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition2296-236010.3389/fped.2021.560720https://doaj.org/article/178a167fcbc74549bcaf724ae8187aed2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.560720/fullhttps://doaj.org/toc/2296-2360Context: Hyperuricemia is defined when the plasma uric acid concentration is above 416 μmol/L (7 mg/dl) in male adults, or 357 μmol/L (6 mg/dl) in female adults. However, there are no explicit criteria yet for children.Objective: It is necessary to set up reference intervals for the uric acid level in different age groups among children.Materials and Methods: A total of 5,439 individuals (3,258 males, 2,181 females) were included in the final statistical analysis. Reference values of all age groups were determined by statistical descriptions. Multiple linear regression analysis was applied to determine the relationship between uric acid level, BMI, and age.Results: The level of uric acid increased with age. Gender differences in uric acid level occurred after the onset of puberty. Additionally, linear regression revealed a positive correlation between the uric acid level and BMI.Discussion and Conclusion: The reference range of the uric acid level in children is inconsistent with the previous viewpoint. Body mass index plays an important role in uric acid metabolism.Chengjun DaiChaoban WangFangqin XiaZishuo LiuYiqi MoXiaoou ShanYonghai ZhouFrontiers Media S.A.articleuric acidchildrenreference intervalSoutheast Chinabody mass indexPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uric acid children reference interval Southeast China body mass index Pediatrics RJ1-570
spellingShingle	uric acid children reference interval Southeast China body mass index Pediatrics RJ1-570 Chengjun Dai Chaoban Wang Fangqin Xia Zishuo Liu Yiqi Mo Xiaoou Shan Yonghai Zhou Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition
description	Context: Hyperuricemia is defined when the plasma uric acid concentration is above 416 μmol/L (7 mg/dl) in male adults, or 357 μmol/L (6 mg/dl) in female adults. However, there are no explicit criteria yet for children.Objective: It is necessary to set up reference intervals for the uric acid level in different age groups among children.Materials and Methods: A total of 5,439 individuals (3,258 males, 2,181 females) were included in the final statistical analysis. Reference values of all age groups were determined by statistical descriptions. Multiple linear regression analysis was applied to determine the relationship between uric acid level, BMI, and age.Results: The level of uric acid increased with age. Gender differences in uric acid level occurred after the onset of puberty. Additionally, linear regression revealed a positive correlation between the uric acid level and BMI.Discussion and Conclusion: The reference range of the uric acid level in children is inconsistent with the previous viewpoint. Body mass index plays an important role in uric acid metabolism.
format	article
author	Chengjun Dai Chaoban Wang Fangqin Xia Zishuo Liu Yiqi Mo Xiaoou Shan Yonghai Zhou
author_facet	Chengjun Dai Chaoban Wang Fangqin Xia Zishuo Liu Yiqi Mo Xiaoou Shan Yonghai Zhou
author_sort	Chengjun Dai
title	Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition
title_short	Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition
title_full	Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition
title_fullStr	Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition
title_full_unstemmed	Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition
title_sort	age and gender-specific reference intervals for uric acid level in children aged 5–14 years in southeast zhejiang province of china: hyperuricemia in children may need redefinition
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/178a167fcbc74549bcaf724ae8187aed
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Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition

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