C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells

Abstract Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role remains unclear in renal cell carcinoma (RCC). In this...

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Autores principales:	Yong Wang, Donghe Fu, Jing Su, Yajing Chen, Can Qi, Yin Sun, Yuanjie Niu, Ning Zhang, Dan Yue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/178b5436c2484fa38bb8ff14981b02e4
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spelling	oai:doaj.org-article:178b5436c2484fa38bb8ff14981b02e42021-12-02T15:06:16ZC1QBP suppresses cell adhesion and metastasis of renal carcinoma cells10.1038/s41598-017-01084-w2045-2322https://doaj.org/article/178b5436c2484fa38bb8ff14981b02e42017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01084-whttps://doaj.org/toc/2045-2322Abstract Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role remains unclear in renal cell carcinoma (RCC). In this study, C1QBP knockdown in RCC cell influenced expression of multiple genes associated with cell adhesion, among which L1 cell adhesion molecule (L1CAM) was significantly higher upon a reduction of C1QBP. In turn, cell adhesion and invasion abilities were significantly increased with increased metastasis to lung and liver in vivo. C1QBP may regulate RCC cell adhesion and invasion through influencing the p-GSK3/β-Catenin/L1CAM expression. Over all, our study demonstrated that C1QBP could regulate RCC metastasis by regulating the GSK3/β-Catenin/L1CAM signaling pathway.Yong WangDonghe FuJing SuYajing ChenCan QiYin SunYuanjie NiuNing ZhangDan YueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Wang Donghe Fu Jing Su Yajing Chen Can Qi Yin Sun Yuanjie Niu Ning Zhang Dan Yue C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
description	Abstract Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role remains unclear in renal cell carcinoma (RCC). In this study, C1QBP knockdown in RCC cell influenced expression of multiple genes associated with cell adhesion, among which L1 cell adhesion molecule (L1CAM) was significantly higher upon a reduction of C1QBP. In turn, cell adhesion and invasion abilities were significantly increased with increased metastasis to lung and liver in vivo. C1QBP may regulate RCC cell adhesion and invasion through influencing the p-GSK3/β-Catenin/L1CAM expression. Over all, our study demonstrated that C1QBP could regulate RCC metastasis by regulating the GSK3/β-Catenin/L1CAM signaling pathway.
format	article
author	Yong Wang Donghe Fu Jing Su Yajing Chen Can Qi Yin Sun Yuanjie Niu Ning Zhang Dan Yue
author_facet	Yong Wang Donghe Fu Jing Su Yajing Chen Can Qi Yin Sun Yuanjie Niu Ning Zhang Dan Yue
author_sort	Yong Wang
title	C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_short	C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_full	C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_fullStr	C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_full_unstemmed	C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_sort	c1qbp suppresses cell adhesion and metastasis of renal carcinoma cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/178b5436c2484fa38bb8ff14981b02e4
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_version_	1718388497261264896

C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells

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