Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent

Li-Hua Deng,1,2 Hai Jiang,1 Fu-Lin Lu,1 Han-Wei Wang,1 Yu Pu,1 Chang-Qiang Wu,1 Hong-Jie Tang,3 Ye Xu,4 Tian-Wu Chen,1 Jiang Zhu,1 Cheng-Yi Shen,1 Xiao-Ming Zhang1 1Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging, Affiliated Hospital of North Sichuan Medical College,...

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Autores principales:	Deng LH, Jiang H, Lu FL, Wang HW, Pu Y, Wu CQ, Tang HJ, Xu Y, Chen TW, Zhu J, Shen CY, Zhang XM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	magnetic resonance imaging contrast agents superparamagnetic iron oxide polyethylene glycol Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/178d80d069d24fc9bd31b0ad65f874e9
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spelling	oai:doaj.org-article:178d80d069d24fc9bd31b0ad65f874e92021-12-02T13:35:41ZSize and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent1178-2013https://doaj.org/article/178d80d069d24fc9bd31b0ad65f874e92021-01-01T00:00:00Zhttps://www.dovepress.com/size-and-peg-length-controlled-pegylated-monocrystalline-superparamagn-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Li-Hua Deng,1,2 Hai Jiang,1 Fu-Lin Lu,1 Han-Wei Wang,1 Yu Pu,1 Chang-Qiang Wu,1 Hong-Jie Tang,3 Ye Xu,4 Tian-Wu Chen,1 Jiang Zhu,1 Cheng-Yi Shen,1 Xiao-Ming Zhang1 1Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China; 2Department of Radiology, First People’s Hospital of Neijiang, Neijiang 641000, People’s Republic of China; 3Department of Radiology, Nanchong Hospital of Traditional Chinese Medicine, Nanchong 637000, People’s Republic of China; 4Department of Radiology, Children’s Hospital of Chongqing Medical University, Chongqing 401122, People’s Republic of ChinaCorrespondence: Chang-Qiang Wu; Xiaoming ZhangSichuan Key Laboratory of Medical Imaging and School of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, 234th Fujiang Road, Nanchong 637000, People’s Republic of ChinaTel +86-13990723836Email wucq1984@163.com; zhangxm@nsmc.edu.cnObjective: PEGylated superparamagnetic iron oxide (SPIO) is the most promising alternatives to gadolinium-based contrast agents (GBCAs) in MRI. This paper is to explore the imaging effects of PEGylated SPIO, which is influenced by particle sizes and surface polyethylene glycol (PEG) coating, using as MRI contrast agents at different magnetic field intensities.Methods: Firstly, nine PEGylated monocrystalline SPIO nanoparticles with different nanocrystal sizes and different molecular weights PEG coating were prepared, and then physical and biological properties were analyzed. Finally, MRI imaging in vivo was performed to observe the imaging performance.Results: Nine PEGylated monocrystalline SPIO nanoparticles have good relaxivities, serum stability, and biosecurity. At the same time, they show different imaging characteristics at different magnetic field intensities. Eight-nanometer SPIO@PEG5k is an effective T2 contrast agent at 3.0 T (r2/r1 = 14.0), is an ideal T1-T2 dual-mode contrast agent at 1.5 T (r2/r1 = 6.52), and is also an effective T1 contrast agent at 0.5 T (r2/r1 = 2.49), while 4-nm SPIO@PEG5k is a T1-T2 dual-mode contrast agent at 3.0 T (r2/r1 = 5.24), and is a useful T1 contrast agent at 0.5 T (r2/r1 = 1.74) and 1.5 T (r2/r1 = 2.85). MRI studies in vivo at 3.0 T further confirm that 4-nm SPIO@PEG5k displays excellent T1-T2 dual-mode contrast enhancement, whereas 8-nm SPIO@PEG5k only displays T2 contrast enhancement.Conclusion: PEGylated SPIOs with different nanocrystal sizes and PEG coating can be used as T1, T2, or T1-T2 dual-mode contrast agents to meet the clinical demands of MRI at specific magnetic fields.Keywords: magnetic resonance imaging, contrast agents, superparamagnetic iron oxide, polyethylene glycolDeng LHJiang HLu FLWang HWPu YWu CQTang HJXu YChen TWZhu JShen CYZhang XMDove Medical Pressarticlemagnetic resonance imagingcontrast agentssuperparamagnetic iron oxidepolyethylene glycolMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 201-211 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic resonance imaging contrast agents superparamagnetic iron oxide polyethylene glycol Medicine (General) R5-920
spellingShingle	magnetic resonance imaging contrast agents superparamagnetic iron oxide polyethylene glycol Medicine (General) R5-920 Deng LH Jiang H Lu FL Wang HW Pu Y Wu CQ Tang HJ Xu Y Chen TW Zhu J Shen CY Zhang XM Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent
description	Li-Hua Deng,1,2 Hai Jiang,1 Fu-Lin Lu,1 Han-Wei Wang,1 Yu Pu,1 Chang-Qiang Wu,1 Hong-Jie Tang,3 Ye Xu,4 Tian-Wu Chen,1 Jiang Zhu,1 Cheng-Yi Shen,1 Xiao-Ming Zhang1 1Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China; 2Department of Radiology, First People’s Hospital of Neijiang, Neijiang 641000, People’s Republic of China; 3Department of Radiology, Nanchong Hospital of Traditional Chinese Medicine, Nanchong 637000, People’s Republic of China; 4Department of Radiology, Children’s Hospital of Chongqing Medical University, Chongqing 401122, People’s Republic of ChinaCorrespondence: Chang-Qiang Wu; Xiaoming ZhangSichuan Key Laboratory of Medical Imaging and School of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, 234th Fujiang Road, Nanchong 637000, People’s Republic of ChinaTel +86-13990723836Email wucq1984@163.com; zhangxm@nsmc.edu.cnObjective: PEGylated superparamagnetic iron oxide (SPIO) is the most promising alternatives to gadolinium-based contrast agents (GBCAs) in MRI. This paper is to explore the imaging effects of PEGylated SPIO, which is influenced by particle sizes and surface polyethylene glycol (PEG) coating, using as MRI contrast agents at different magnetic field intensities.Methods: Firstly, nine PEGylated monocrystalline SPIO nanoparticles with different nanocrystal sizes and different molecular weights PEG coating were prepared, and then physical and biological properties were analyzed. Finally, MRI imaging in vivo was performed to observe the imaging performance.Results: Nine PEGylated monocrystalline SPIO nanoparticles have good relaxivities, serum stability, and biosecurity. At the same time, they show different imaging characteristics at different magnetic field intensities. Eight-nanometer SPIO@PEG5k is an effective T2 contrast agent at 3.0 T (r2/r1 = 14.0), is an ideal T1-T2 dual-mode contrast agent at 1.5 T (r2/r1 = 6.52), and is also an effective T1 contrast agent at 0.5 T (r2/r1 = 2.49), while 4-nm SPIO@PEG5k is a T1-T2 dual-mode contrast agent at 3.0 T (r2/r1 = 5.24), and is a useful T1 contrast agent at 0.5 T (r2/r1 = 1.74) and 1.5 T (r2/r1 = 2.85). MRI studies in vivo at 3.0 T further confirm that 4-nm SPIO@PEG5k displays excellent T1-T2 dual-mode contrast enhancement, whereas 8-nm SPIO@PEG5k only displays T2 contrast enhancement.Conclusion: PEGylated SPIOs with different nanocrystal sizes and PEG coating can be used as T1, T2, or T1-T2 dual-mode contrast agents to meet the clinical demands of MRI at specific magnetic fields.Keywords: magnetic resonance imaging, contrast agents, superparamagnetic iron oxide, polyethylene glycol
format	article
author	Deng LH Jiang H Lu FL Wang HW Pu Y Wu CQ Tang HJ Xu Y Chen TW Zhu J Shen CY Zhang XM
author_facet	Deng LH Jiang H Lu FL Wang HW Pu Y Wu CQ Tang HJ Xu Y Chen TW Zhu J Shen CY Zhang XM
author_sort	Deng LH
title	Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent
title_short	Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent
title_full	Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent
title_fullStr	Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent
title_full_unstemmed	Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent
title_sort	size and peg length-controlled pegylated monocrystalline superparamagnetic iron oxide nanocomposite for mri contrast agent
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/178d80d069d24fc9bd31b0ad65f874e9
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Size and PEG Length-Controlled PEGylated Monocrystalline Superparamagnetic Iron Oxide Nanocomposite for MRI Contrast Agent

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