The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Abstract Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research col...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeroen W. G. Derksen, Geraldine R. Vink, Marloes A. G. Elferink, Jeanine M. L. Roodhart, Helena M. Verkooijen, Wilhelmina M. U. van Grevenstein, Peter D. Siersema, Anne M. May, Miriam Koopman, The PLCRC Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/179162c857894da7b1109e3921ce2513
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:179162c857894da7b1109e3921ce2513
record_format	dspace
spelling	oai:doaj.org-article:179162c857894da7b1109e3921ce25132021-12-02T14:21:50ZThe Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care10.1038/s41598-020-79890-y2045-2322https://doaj.org/article/179162c857894da7b1109e3921ce25132021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79890-yhttps://doaj.org/toc/2045-2322Abstract Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system.Jeroen W. G. DerksenGeraldine R. VinkMarloes A. G. ElferinkJeanine M. L. RoodhartHelena M. VerkooijenWilhelmina M. U. van GrevensteinPeter D. SiersemaAnne M. MayMiriam KoopmanThe PLCRC Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeroen W. G. Derksen Geraldine R. Vink Marloes A. G. Elferink Jeanine M. L. Roodhart Helena M. Verkooijen Wilhelmina M. U. van Grevenstein Peter D. Siersema Anne M. May Miriam Koopman The PLCRC Study Group The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
description	Abstract Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system.
format	article
author	Jeroen W. G. Derksen Geraldine R. Vink Marloes A. G. Elferink Jeanine M. L. Roodhart Helena M. Verkooijen Wilhelmina M. U. van Grevenstein Peter D. Siersema Anne M. May Miriam Koopman The PLCRC Study Group
author_facet	Jeroen W. G. Derksen Geraldine R. Vink Marloes A. G. Elferink Jeanine M. L. Roodhart Helena M. Verkooijen Wilhelmina M. U. van Grevenstein Peter D. Siersema Anne M. May Miriam Koopman The PLCRC Study Group
author_sort	Jeroen W. G. Derksen
title	The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
title_short	The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
title_full	The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
title_fullStr	The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
title_full_unstemmed	The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care
title_sort	prospective dutch colorectal cancer (plcrc) cohort: real-world data facilitating research and clinical care
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/179162c857894da7b1109e3921ce2513
work_keys_str_mv	AT jeroenwgderksen theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT geraldinervink theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT marloesagelferink theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT jeaninemlroodhart theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT helenamverkooijen theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT wilhelminamuvangrevenstein theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT peterdsiersema theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT annemmay theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT miriamkoopman theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT theplcrcstudygroup theprospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT jeroenwgderksen prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT geraldinervink prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT marloesagelferink prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT jeaninemlroodhart prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT helenamverkooijen prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT wilhelminamuvangrevenstein prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT peterdsiersema prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT annemmay prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT miriamkoopman prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare AT theplcrcstudygroup prospectivedutchcolorectalcancerplcrccohortrealworlddatafacilitatingresearchandclinicalcare
_version_	1718391470760656896

The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Ejemplares similares