Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control

Abstract Basal ganglia (BG) are involved in inhibitory control (IC) and known to change in structure and activation along the menstrual cycle. Therefore, we investigated BG activation and connectivity patterns related to IC during different cycle phases. Thirty-six naturally cycling women were scann...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Esmeralda Hidalgo-Lopez, Belinda Pletzer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17946e0de1c5402da78b09a375fd086d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:17946e0de1c5402da78b09a375fd086d
record_format	dspace
spelling	oai:doaj.org-article:17946e0de1c5402da78b09a375fd086d2021-12-02T15:08:59ZIndividual differences in the effect of menstrual cycle on basal ganglia inhibitory control10.1038/s41598-019-47426-82045-2322https://doaj.org/article/17946e0de1c5402da78b09a375fd086d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47426-8https://doaj.org/toc/2045-2322Abstract Basal ganglia (BG) are involved in inhibitory control (IC) and known to change in structure and activation along the menstrual cycle. Therefore, we investigated BG activation and connectivity patterns related to IC during different cycle phases. Thirty-six naturally cycling women were scanned three times performing a Stop Signal Task and hormonal levels analysed from saliva samples. We found an impaired Stop signal reaction time (SSRT) during pre-ovulatory compared to menses the higher the baseline IC of women. Blood oxygen level dependent (BOLD)-response in bilateral putamen significantly decreased during the luteal phase. Connectivity strength from the left putamen displayed an interactive effect of cycle and IC. During pre-ovulatory the connectivity with anterior cingulate cortex and left inferior parietal lobe was significantly stronger the higher the IC, and during luteal with left supplementary motor area. Right putamen’s activation and left hemisphere’s connectivity predicted the SSRT across participants. Therefore, we propose a compensatory mechanism for the hormonal changes across the menstrual cycle based on a lateralized pattern.Esmeralda Hidalgo-LopezBelinda PletzerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Esmeralda Hidalgo-Lopez Belinda Pletzer Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control
description	Abstract Basal ganglia (BG) are involved in inhibitory control (IC) and known to change in structure and activation along the menstrual cycle. Therefore, we investigated BG activation and connectivity patterns related to IC during different cycle phases. Thirty-six naturally cycling women were scanned three times performing a Stop Signal Task and hormonal levels analysed from saliva samples. We found an impaired Stop signal reaction time (SSRT) during pre-ovulatory compared to menses the higher the baseline IC of women. Blood oxygen level dependent (BOLD)-response in bilateral putamen significantly decreased during the luteal phase. Connectivity strength from the left putamen displayed an interactive effect of cycle and IC. During pre-ovulatory the connectivity with anterior cingulate cortex and left inferior parietal lobe was significantly stronger the higher the IC, and during luteal with left supplementary motor area. Right putamen’s activation and left hemisphere’s connectivity predicted the SSRT across participants. Therefore, we propose a compensatory mechanism for the hormonal changes across the menstrual cycle based on a lateralized pattern.
format	article
author	Esmeralda Hidalgo-Lopez Belinda Pletzer
author_facet	Esmeralda Hidalgo-Lopez Belinda Pletzer
author_sort	Esmeralda Hidalgo-Lopez
title	Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control
title_short	Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control
title_full	Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control
title_fullStr	Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control
title_full_unstemmed	Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control
title_sort	individual differences in the effect of menstrual cycle on basal ganglia inhibitory control
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/17946e0de1c5402da78b09a375fd086d
work_keys_str_mv	AT esmeraldahidalgolopez individualdifferencesintheeffectofmenstrualcycleonbasalgangliainhibitorycontrol AT belindapletzer individualdifferencesintheeffectofmenstrualcycleonbasalgangliainhibitorycontrol
_version_	1718387922473844736

Individual differences in the effect of menstrual cycle on basal ganglia inhibitory control

Ejemplares similares