Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

The human chromosome locus 9p21.3 is a tumour suppressor hub which encodes three CDK inhibitors, p15INK4B, p14ARF and p16INK4A. Here, the authors show that p15INK4B inhibits the cell cycle and glycolysis in a murine model of HRas + ‐mediated urothelial carcinoma and has a more relevant role as a tum...

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Autores principales:	Yong Xia, Yan Liu, Chao Yang, Diane M. Simeone, Tung-Tien Sun, David J. DeGraff, Moon-shong Tang, Yingkai Zhang, Xue-Ru Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1794a8df136e4fa498e705b2124da7e9
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spelling	oai:doaj.org-article:1794a8df136e4fa498e705b2124da7e92021-12-02T14:17:30ZDominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis10.1038/s41467-021-22327-52041-1723https://doaj.org/article/1794a8df136e4fa498e705b2124da7e92021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22327-5https://doaj.org/toc/2041-1723The human chromosome locus 9p21.3 is a tumour suppressor hub which encodes three CDK inhibitors, p15INK4B, p14ARF and p16INK4A. Here, the authors show that p15INK4B inhibits the cell cycle and glycolysis in a murine model of HRas + ‐mediated urothelial carcinoma and has a more relevant role as a tumour suppressor than its neighbouring p16INK4A.Yong XiaYan LiuChao YangDiane M. SimeoneTung-Tien SunDavid J. DeGraffMoon-shong TangYingkai ZhangXue-Ru WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong Xia Yan Liu Chao Yang Diane M. Simeone Tung-Tien Sun David J. DeGraff Moon-shong Tang Yingkai Zhang Xue-Ru Wu Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
description	The human chromosome locus 9p21.3 is a tumour suppressor hub which encodes three CDK inhibitors, p15INK4B, p14ARF and p16INK4A. Here, the authors show that p15INK4B inhibits the cell cycle and glycolysis in a murine model of HRas + ‐mediated urothelial carcinoma and has a more relevant role as a tumour suppressor than its neighbouring p16INK4A.
format	article
author	Yong Xia Yan Liu Chao Yang Diane M. Simeone Tung-Tien Sun David J. DeGraff Moon-shong Tang Yingkai Zhang Xue-Ru Wu
author_facet	Yong Xia Yan Liu Chao Yang Diane M. Simeone Tung-Tien Sun David J. DeGraff Moon-shong Tang Yingkai Zhang Xue-Ru Wu
author_sort	Yong Xia
title	Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
title_short	Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
title_full	Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
title_fullStr	Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
title_full_unstemmed	Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
title_sort	dominant role of cdkn2b/p15ink4b of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1794a8df136e4fa498e705b2124da7e9
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Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

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