Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

The emergence of sub-clones that are resistant to targeted agents is a major therapeutic obstacle in oncology. Here, using colorectal cancer as a model system, the authors show that interfering with ancestral oncogenic events present in all subclones-like APC-WNT pathway alterations—can restrain the...

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Autores principales:	Mariangela Russo, Simona Lamba, Annalisa Lorenzato, Alberto Sogari, Giorgio Corti, Giuseppe Rospo, Benedetta Mussolin, Monica Montone, Luca Lazzari, Sabrina Arena, Daniele Oddo, Michael Linnebacher, Andrea Sartore-Bianchi, Filippo Pietrantonio, Salvatore Siena, Federica Di Nicolantonio, Alberto Bardelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1796a9062fbe4ab08a446eddf05ffcac
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spelling	oai:doaj.org-article:1796a9062fbe4ab08a446eddf05ffcac2021-12-02T16:56:36ZReliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies10.1038/s41467-018-04506-z2041-1723https://doaj.org/article/1796a9062fbe4ab08a446eddf05ffcac2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04506-zhttps://doaj.org/toc/2041-1723The emergence of sub-clones that are resistant to targeted agents is a major therapeutic obstacle in oncology. Here, using colorectal cancer as a model system, the authors show that interfering with ancestral oncogenic events present in all subclones-like APC-WNT pathway alterations—can restrain the emergence of drug-resistant populations.Mariangela RussoSimona LambaAnnalisa LorenzatoAlberto SogariGiorgio CortiGiuseppe RospoBenedetta MussolinMonica MontoneLuca LazzariSabrina ArenaDaniele OddoMichael LinnebacherAndrea Sartore-BianchiFilippo PietrantonioSalvatore SienaFederica Di NicolantonioAlberto BardelliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariangela Russo Simona Lamba Annalisa Lorenzato Alberto Sogari Giorgio Corti Giuseppe Rospo Benedetta Mussolin Monica Montone Luca Lazzari Sabrina Arena Daniele Oddo Michael Linnebacher Andrea Sartore-Bianchi Filippo Pietrantonio Salvatore Siena Federica Di Nicolantonio Alberto Bardelli Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
description	The emergence of sub-clones that are resistant to targeted agents is a major therapeutic obstacle in oncology. Here, using colorectal cancer as a model system, the authors show that interfering with ancestral oncogenic events present in all subclones-like APC-WNT pathway alterations—can restrain the emergence of drug-resistant populations.
format	article
author	Mariangela Russo Simona Lamba Annalisa Lorenzato Alberto Sogari Giorgio Corti Giuseppe Rospo Benedetta Mussolin Monica Montone Luca Lazzari Sabrina Arena Daniele Oddo Michael Linnebacher Andrea Sartore-Bianchi Filippo Pietrantonio Salvatore Siena Federica Di Nicolantonio Alberto Bardelli
author_facet	Mariangela Russo Simona Lamba Annalisa Lorenzato Alberto Sogari Giorgio Corti Giuseppe Rospo Benedetta Mussolin Monica Montone Luca Lazzari Sabrina Arena Daniele Oddo Michael Linnebacher Andrea Sartore-Bianchi Filippo Pietrantonio Salvatore Siena Federica Di Nicolantonio Alberto Bardelli
author_sort	Mariangela Russo
title	Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
title_short	Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
title_full	Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
title_fullStr	Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
title_full_unstemmed	Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
title_sort	reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1796a9062fbe4ab08a446eddf05ffcac
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Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies

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