Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke

Ischemic stroke is a common acute cerebrovascular disease in the middle-aged and elderly,and one of the most fatal diseases in the world.There are limited treatment options that currently exist and only apply to a small proportion of stroke patients,so developing effective treatments to reduce brain...

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Autores principales:	Xiaomei SU, Danshen ZHANG
Formato:	article
Lenguaje:	ZH
Publicado:	Hebei University of Science and Technology 2021
Materias:	neurobiochemistry; astrocyte; mitochondria; ischemic stroke; brain damage Technology T
Acceso en línea:	https://doaj.org/article/179806f0a1b241268dc074b4bf2ecc57
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spelling	oai:doaj.org-article:179806f0a1b241268dc074b4bf2ecc572021-11-23T07:08:58ZDiscussion of astrocytic mitochondria as a therapeutic target for ischemic stroke1008-154210.7535/hbkd.2021yx04010https://doaj.org/article/179806f0a1b241268dc074b4bf2ecc572021-08-01T00:00:00Zhttp://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b202104010&flag=1&journal_https://doaj.org/toc/1008-1542Ischemic stroke is a common acute cerebrovascular disease in the middle-aged and elderly,and one of the most fatal diseases in the world.There are limited treatment options that currently exist and only apply to a small proportion of stroke patients,so developing effective treatments to reduce brain damage is critical.Astrocytes are the core components of the central nervous system.Mitochondrial dysfunction is the initial event of ischemic stroke and plays an important role in neuronal survival and neurological function improvement.In this paper,based on the role of astrocytic mitochondria in the pathogenesis of ischemic stroke,the changes of the biological energy and dynamics of astrocytic mitochondria,the functional transfer to neurons and the regulation of astrocytic mitochondria on cerebral blood flow by astrocytic mitochondrice were discussed.Emphasized that astrocytic mitochondria can be used as one of the targets for the treatment of ischemic stroke,so as to better understand the role of astrocytic mitochondria in the process of ischemia-induced neuronal death,and to provide a theoretical basis for the new treatment of ischemic stroke.Xiaomei SUDanshen ZHANGHebei University of Science and Technologyarticleneurobiochemistry; astrocyte; mitochondria; ischemic stroke; brain damageTechnologyTZHJournal of Hebei University of Science and Technology, Vol 42, Iss 4, Pp 400-409 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	neurobiochemistry; astrocyte; mitochondria; ischemic stroke; brain damage Technology T
spellingShingle	neurobiochemistry; astrocyte; mitochondria; ischemic stroke; brain damage Technology T Xiaomei SU Danshen ZHANG Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
description	Ischemic stroke is a common acute cerebrovascular disease in the middle-aged and elderly,and one of the most fatal diseases in the world.There are limited treatment options that currently exist and only apply to a small proportion of stroke patients,so developing effective treatments to reduce brain damage is critical.Astrocytes are the core components of the central nervous system.Mitochondrial dysfunction is the initial event of ischemic stroke and plays an important role in neuronal survival and neurological function improvement.In this paper,based on the role of astrocytic mitochondria in the pathogenesis of ischemic stroke,the changes of the biological energy and dynamics of astrocytic mitochondria,the functional transfer to neurons and the regulation of astrocytic mitochondria on cerebral blood flow by astrocytic mitochondrice were discussed.Emphasized that astrocytic mitochondria can be used as one of the targets for the treatment of ischemic stroke,so as to better understand the role of astrocytic mitochondria in the process of ischemia-induced neuronal death,and to provide a theoretical basis for the new treatment of ischemic stroke.
format	article
author	Xiaomei SU Danshen ZHANG
author_facet	Xiaomei SU Danshen ZHANG
author_sort	Xiaomei SU
title	Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
title_short	Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
title_full	Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
title_fullStr	Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
title_full_unstemmed	Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
title_sort	discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke
publisher	Hebei University of Science and Technology
publishDate	2021
url	https://doaj.org/article/179806f0a1b241268dc074b4bf2ecc57
work_keys_str_mv	AT xiaomeisu discussionofastrocyticmitochondriaasatherapeutictargetforischemicstroke AT danshenzhang discussionofastrocyticmitochondriaasatherapeutictargetforischemicstroke
_version_	1718416809793683456

Discussion of astrocytic mitochondria as a therapeutic target for ischemic stroke

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