Effects of growth and mutation on pattern formation in tissues.

In many developing tissues, neighboring cells enter different developmental pathways, resulting in a fine-grained pattern of different cell states. The most common mechanism that generates such patterns is lateral inhibition, for example through Delta-Notch coupling. In this work, we simulate growth...

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Autores principales:	Benedicte Mengel Pers, Sandeep Krishna, Sagar Chakraborty, Simone Pigolotti, Vedran Sekara, Szabolcs Semsey, Mogens H Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/179a850b9b9e4fdea9bedd0f9f5f771a
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id	oai:doaj.org-article:179a850b9b9e4fdea9bedd0f9f5f771a
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spelling	oai:doaj.org-article:179a850b9b9e4fdea9bedd0f9f5f771a2021-11-18T08:09:40ZEffects of growth and mutation on pattern formation in tissues.1932-620310.1371/journal.pone.0048772https://doaj.org/article/179a850b9b9e4fdea9bedd0f9f5f771a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144963/?tool=EBIhttps://doaj.org/toc/1932-6203In many developing tissues, neighboring cells enter different developmental pathways, resulting in a fine-grained pattern of different cell states. The most common mechanism that generates such patterns is lateral inhibition, for example through Delta-Notch coupling. In this work, we simulate growth of tissues consisting of a hexagonal arrangement of cells laterally inhibiting their neighbors. We find that tissue growth by cell division and cell migration tends to produce ordered patterns, whereas lateral growth leads to disordered, patchy patterns. Ordered patterns are very robust to mutations (gene silencing or activation) in single cells. In contrast, mutation in a cell of a disordered tissue can produce a larger and more widespread perturbation of the pattern. In tissues where ordered and disordered patches coexist, the perturbations spread mostly at boundaries between patches. If cell division occurs on time scales faster than the degradation time, disordered patches will appear. Our work suggests that careful experimental characterization of the disorder in tissues could pinpoint where and how the tissue is susceptible to large-scale damage even from single cell mutations.Benedicte Mengel PersSandeep KrishnaSagar ChakrabortySimone PigolottiVedran SekaraSzabolcs SemseyMogens H JensenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48772 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benedicte Mengel Pers Sandeep Krishna Sagar Chakraborty Simone Pigolotti Vedran Sekara Szabolcs Semsey Mogens H Jensen Effects of growth and mutation on pattern formation in tissues.
description	In many developing tissues, neighboring cells enter different developmental pathways, resulting in a fine-grained pattern of different cell states. The most common mechanism that generates such patterns is lateral inhibition, for example through Delta-Notch coupling. In this work, we simulate growth of tissues consisting of a hexagonal arrangement of cells laterally inhibiting their neighbors. We find that tissue growth by cell division and cell migration tends to produce ordered patterns, whereas lateral growth leads to disordered, patchy patterns. Ordered patterns are very robust to mutations (gene silencing or activation) in single cells. In contrast, mutation in a cell of a disordered tissue can produce a larger and more widespread perturbation of the pattern. In tissues where ordered and disordered patches coexist, the perturbations spread mostly at boundaries between patches. If cell division occurs on time scales faster than the degradation time, disordered patches will appear. Our work suggests that careful experimental characterization of the disorder in tissues could pinpoint where and how the tissue is susceptible to large-scale damage even from single cell mutations.
format	article
author	Benedicte Mengel Pers Sandeep Krishna Sagar Chakraborty Simone Pigolotti Vedran Sekara Szabolcs Semsey Mogens H Jensen
author_facet	Benedicte Mengel Pers Sandeep Krishna Sagar Chakraborty Simone Pigolotti Vedran Sekara Szabolcs Semsey Mogens H Jensen
author_sort	Benedicte Mengel Pers
title	Effects of growth and mutation on pattern formation in tissues.
title_short	Effects of growth and mutation on pattern formation in tissues.
title_full	Effects of growth and mutation on pattern formation in tissues.
title_fullStr	Effects of growth and mutation on pattern formation in tissues.
title_full_unstemmed	Effects of growth and mutation on pattern formation in tissues.
title_sort	effects of growth and mutation on pattern formation in tissues.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/179a850b9b9e4fdea9bedd0f9f5f771a
work_keys_str_mv	AT benedictemengelpers effectsofgrowthandmutationonpatternformationintissues AT sandeepkrishna effectsofgrowthandmutationonpatternformationintissues AT sagarchakraborty effectsofgrowthandmutationonpatternformationintissues AT simonepigolotti effectsofgrowthandmutationonpatternformationintissues AT vedransekara effectsofgrowthandmutationonpatternformationintissues AT szabolcssemsey effectsofgrowthandmutationonpatternformationintissues AT mogenshjensen effectsofgrowthandmutationonpatternformationintissues
_version_	1718422091070439424

Effects of growth and mutation on pattern formation in tissues.

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