Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.

COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twe...

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Autores principales:	Manna Zhang, Lin Li, Ma Luo, Binhua Liang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/179afe361a1d4d0cba793c9fe1677d81
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spelling	oai:doaj.org-article:179afe361a1d4d0cba793c9fe1677d812021-12-02T20:18:56ZGenomic characterization and evolution of SARS-CoV-2 of a Canadian population.1932-620310.1371/journal.pone.0247799https://doaj.org/article/179afe361a1d4d0cba793c9fe1677d812021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0247799https://doaj.org/toc/1932-6203COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twenty-one substitutions that have frequencies greater than 3% of viral population were identified. Analysis of these substitutions indicated that P1427I (ORF1b), Y1464C (ORF1b), and Q57H (ORF3a) might affect functions of the corresponding SARS-CoV-2 encoded proteins. Additionally, we found the evidence of positive selection on the ORF3a and codon 614 of Spike protein, suggesting the viral components responsible for host entry and activation of inflammation response were targeted by host immune responses. The study showed genomic variation and evolution of SARS-CoV-2 in a Canadian population. These information may help develop preventive strategies and be used for further study of SARS-CoV-2 pathogenesis and therapeutics development.Manna ZhangLin LiMa LuoBinhua LiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 3, p e0247799 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manna Zhang Lin Li Ma Luo Binhua Liang Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
description	COVID-19 has greatly affected public health and world economy. In this study, we analyzed 129 full-length genomes of SARS-CoV-2 viruses of a Canadian population during early phase of the pandemic. Phylogenetic analysis revealed three major paths of transmission of SARS-CoV-2 viruses into Canada. Twenty-one substitutions that have frequencies greater than 3% of viral population were identified. Analysis of these substitutions indicated that P1427I (ORF1b), Y1464C (ORF1b), and Q57H (ORF3a) might affect functions of the corresponding SARS-CoV-2 encoded proteins. Additionally, we found the evidence of positive selection on the ORF3a and codon 614 of Spike protein, suggesting the viral components responsible for host entry and activation of inflammation response were targeted by host immune responses. The study showed genomic variation and evolution of SARS-CoV-2 in a Canadian population. These information may help develop preventive strategies and be used for further study of SARS-CoV-2 pathogenesis and therapeutics development.
format	article
author	Manna Zhang Lin Li Ma Luo Binhua Liang
author_facet	Manna Zhang Lin Li Ma Luo Binhua Liang
author_sort	Manna Zhang
title	Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
title_short	Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
title_full	Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
title_fullStr	Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
title_full_unstemmed	Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.
title_sort	genomic characterization and evolution of sars-cov-2 of a canadian population.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/179afe361a1d4d0cba793c9fe1677d81
work_keys_str_mv	AT mannazhang genomiccharacterizationandevolutionofsarscov2ofacanadianpopulation AT linli genomiccharacterizationandevolutionofsarscov2ofacanadianpopulation AT maluo genomiccharacterizationandevolutionofsarscov2ofacanadianpopulation AT binhualiang genomiccharacterizationandevolutionofsarscov2ofacanadianpopulation
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Genomic characterization and evolution of SARS-CoV-2 of a Canadian population.

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