Emerging role of SOX11 in mantle cell lymphoma

Venera Kuci,1,2,* Lena Nordström,1,2,* Mats Jerkeman,3 Sara Ek1,2 1Department of Immunotechnology, Lund University, Lund, Sweden; 2CREATE Health, Lund University, Lund, Sweden; 3Department of Oncology, Lund University, Lund, Sweden *These authors contributed equally to this work Abstract...

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Autores principales:	Kuci V, Nordström L, Jerkeman M, Ek S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/179d7397ed614ca48f664b2230123259
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spelling	oai:doaj.org-article:179d7397ed614ca48f664b22301232592021-12-02T07:18:04ZEmerging role of SOX11 in mantle cell lymphoma1179-9889https://doaj.org/article/179d7397ed614ca48f664b22301232592015-02-01T00:00:00Zhttp://www.dovepress.com/emerging-role-of-sox11-in-mantle-cell-lymphoma-peer-reviewed-article-BLCTThttps://doaj.org/toc/1179-9889 Venera Kuci,1,2,* Lena Nordström,1,2,* Mats Jerkeman,3 Sara Ek1,2 1Department of Immunotechnology, Lund University, Lund, Sweden; 2CREATE Health, Lund University, Lund, Sweden; 3Department of Oncology, Lund University, Lund, Sweden *These authors contributed equally to this work Abstract: During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this review, we discuss the emerging role of SOX11 in mantle cell lymphoma and discuss the potential impact in relation to tumorigenesis, diagnostics, prognostics, and therapy. Keywords: SOX11, mantle cell lymphoma, diagnosticKuci VNordström LJerkeman MEk SDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 35-42 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Kuci V Nordström L Jerkeman M Ek S Emerging role of SOX11 in mantle cell lymphoma
description	Venera Kuci,1,2,* Lena Nordström,1,2,* Mats Jerkeman,3 Sara Ek1,2 1Department of Immunotechnology, Lund University, Lund, Sweden; 2CREATE Health, Lund University, Lund, Sweden; 3Department of Oncology, Lund University, Lund, Sweden *These authors contributed equally to this work Abstract: During recent years the neural transcription factor SOX11 has been established as an important biomarker for mantle cell lymphoma. SOX11 is both a diagnostic and prognostic antigen, and may potentially be used for treatment selection for younger patients, in relation to protocols including high dose chemotherapy. The molecular pathways involved are still not fully elucidated and, as SOX11 can interact with several co-transcription factors, functional assays need to be carefully designed to pinpoint SOX11-specific function in a defined cellular context. Furthermore, as SOX11 belongs to a large family of homologous proteins, analysis of SOX11 has been limited by the availability of specific antibodies for detection and pull-down. In this review, we discuss the emerging role of SOX11 in mantle cell lymphoma and discuss the potential impact in relation to tumorigenesis, diagnostics, prognostics, and therapy. Keywords: SOX11, mantle cell lymphoma, diagnostic
format	article
author	Kuci V Nordström L Jerkeman M Ek S
author_facet	Kuci V Nordström L Jerkeman M Ek S
author_sort	Kuci V
title	Emerging role of SOX11 in mantle cell lymphoma
title_short	Emerging role of SOX11 in mantle cell lymphoma
title_full	Emerging role of SOX11 in mantle cell lymphoma
title_fullStr	Emerging role of SOX11 in mantle cell lymphoma
title_full_unstemmed	Emerging role of SOX11 in mantle cell lymphoma
title_sort	emerging role of sox11 in mantle cell lymphoma
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/179d7397ed614ca48f664b2230123259
work_keys_str_mv	AT kuciv emergingroleofsox11inmantlecelllymphoma AT nordstroml emergingroleofsox11inmantlecelllymphoma AT jerkemanm emergingroleofsox11inmantlecelllymphoma AT eks emergingroleofsox11inmantlecelllymphoma
_version_	1718399503198846976

Emerging role of SOX11 in mantle cell lymphoma

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