Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearance and increased susceptibility to bleomycin-induc...

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Autores principales:	Laura A. Hancock, Corinne E. Hennessy, George M. Solomon, Evgenia Dobrinskikh, Alani Estrella, Naoko Hara, David B. Hill, William J. Kissner, Matthew R. Markovetz, Diane E. Grove Villalon, Matthew E. Voss, Guillermo J. Tearney, Kate S. Carroll, Yunlong Shi, Marvin I. Schwarz, William R. Thelin, Steven M. Rowe, Ivana V. Yang, Christopher M. Evans, David A. Schwartz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/179e7c61d4b74fa68c0ec80470732ff6
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spelling	oai:doaj.org-article:179e7c61d4b74fa68c0ec80470732ff62021-12-02T14:39:09ZMuc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice10.1038/s41467-018-07768-92041-1723https://doaj.org/article/179e7c61d4b74fa68c0ec80470732ff62018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07768-9https://doaj.org/toc/2041-1723The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearance and increased susceptibility to bleomycin-induced lung fibrosis, and that both characteristics are reduced by treatment with a mucolytic agent.Laura A. HancockCorinne E. HennessyGeorge M. SolomonEvgenia DobrinskikhAlani EstrellaNaoko HaraDavid B. HillWilliam J. KissnerMatthew R. MarkovetzDiane E. Grove VillalonMatthew E. VossGuillermo J. TearneyKate S. CarrollYunlong ShiMarvin I. SchwarzWilliam R. ThelinSteven M. RoweIvana V. YangChristopher M. EvansDavid A. SchwartzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura A. Hancock Corinne E. Hennessy George M. Solomon Evgenia Dobrinskikh Alani Estrella Naoko Hara David B. Hill William J. Kissner Matthew R. Markovetz Diane E. Grove Villalon Matthew E. Voss Guillermo J. Tearney Kate S. Carroll Yunlong Shi Marvin I. Schwarz William R. Thelin Steven M. Rowe Ivana V. Yang Christopher M. Evans David A. Schwartz Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
description	The promoter variant rs35705950 confers a gain of function to the MUC5B gene and is the dominant risk factor for idiopathic pulmonary fibrosis. Here the authors show that mice overexpressing Muc5b in distal airspaces show impaired mucociliary clearance and increased susceptibility to bleomycin-induced lung fibrosis, and that both characteristics are reduced by treatment with a mucolytic agent.
format	article
author	Laura A. Hancock Corinne E. Hennessy George M. Solomon Evgenia Dobrinskikh Alani Estrella Naoko Hara David B. Hill William J. Kissner Matthew R. Markovetz Diane E. Grove Villalon Matthew E. Voss Guillermo J. Tearney Kate S. Carroll Yunlong Shi Marvin I. Schwarz William R. Thelin Steven M. Rowe Ivana V. Yang Christopher M. Evans David A. Schwartz
author_facet	Laura A. Hancock Corinne E. Hennessy George M. Solomon Evgenia Dobrinskikh Alani Estrella Naoko Hara David B. Hill William J. Kissner Matthew R. Markovetz Diane E. Grove Villalon Matthew E. Voss Guillermo J. Tearney Kate S. Carroll Yunlong Shi Marvin I. Schwarz William R. Thelin Steven M. Rowe Ivana V. Yang Christopher M. Evans David A. Schwartz
author_sort	Laura A. Hancock
title	Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
title_short	Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
title_full	Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
title_fullStr	Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
title_full_unstemmed	Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
title_sort	muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/179e7c61d4b74fa68c0ec80470732ff6
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Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice

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