TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.

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Autores principales: Changwei Yu, Nevena Cvetesic, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Negroni, Petra Hajkova, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D. Vincent, László Tora
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/17a2545846504f2fb6572d460793c1a3
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spelling oai:doaj.org-article:17a2545846504f2fb6572d460793c1a32021-12-02T10:47:59ZTBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage10.1038/s41467-020-20239-42041-1723https://doaj.org/article/17a2545846504f2fb6572d460793c1a32020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20239-4https://doaj.org/toc/2041-1723The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.Changwei YuNevena CvetesicVincent HislerKapil GuptaTao YeEmese GazdagLuc NegroniPetra HajkovaImre BergerBoris LenhardFerenc MüllerStéphane D. VincentLászló ToraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Changwei Yu
Nevena Cvetesic
Vincent Hisler
Kapil Gupta
Tao Ye
Emese Gazdag
Luc Negroni
Petra Hajkova
Imre Berger
Boris Lenhard
Ferenc Müller
Stéphane D. Vincent
László Tora
TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
description The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.
format article
author Changwei Yu
Nevena Cvetesic
Vincent Hisler
Kapil Gupta
Tao Ye
Emese Gazdag
Luc Negroni
Petra Hajkova
Imre Berger
Boris Lenhard
Ferenc Müller
Stéphane D. Vincent
László Tora
author_facet Changwei Yu
Nevena Cvetesic
Vincent Hisler
Kapil Gupta
Tao Ye
Emese Gazdag
Luc Negroni
Petra Hajkova
Imre Berger
Boris Lenhard
Ferenc Müller
Stéphane D. Vincent
László Tora
author_sort Changwei Yu
title TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_short TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_full TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_fullStr TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_full_unstemmed TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage
title_sort tbpl2/tfiia complex establishes the maternal transcriptome through oocyte-specific promoter usage
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/17a2545846504f2fb6572d460793c1a3
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