Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.

<h4>Background</h4>Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely u...

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Autores principales:	Stefan Essig, Nicolas X von der Weid, Marie-Pierre F Strippoli, Cornelia E Rebholz, Gisela Michel, Corina S Rueegg, Felix K Niggli, Claudia E Kuehni, Swiss Pediatric Oncology Group (SPOG)
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17a27f2e3977434d85a86074d6c30f12
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spelling	oai:doaj.org-article:17a27f2e3977434d85a86074d6c30f122021-11-18T07:17:11ZHealth-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.1932-620310.1371/journal.pone.0038015https://doaj.org/article/17a27f2e3977434d85a86074d6c30f122012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22662262/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compare HRQOL of ALL survivors with the general population, and of relapsed with non-relapsed ALL survivors.<h4>Methodology/principal findings</h4>As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976-2003 at age <16 years, survived ≥5 years, and were currently aged ≥16 years. HRQOL was assessed with the Short Form-36 (SF-36), which measures four aspects of physical health and four aspects of mental health. A score of 50 corresponded to the mean of a healthy reference population. We analyzed data from 457 ALL survivors (response: 79%). Sixty-one survivors had suffered a relapse. Compared to the general population, ALL survivors reported similar or higher HRQOL scores on all scales. Survivors with a relapse scored lower in general health perceptions (51.6) compared to those without (55.8;p=0.005), but after adjusting for self-reported late effects, this difference disappeared.<h4>Conclusion/significance</h4>Compared to population norms, ALL survivors reported good HRQOL, even after a relapse. However, relapsed ALL survivors reported poorer general health than non-relapsed. Therefore, we encourage specialists to screen for poor general health in survivors after a relapse and, when appropriate, specifically seek and treat underlying late effects. This will help to improve patients' HRQOL.Stefan EssigNicolas X von der WeidMarie-Pierre F StrippoliCornelia E RebholzGisela MichelCorina S RueeggFelix K NiggliClaudia E KuehniSwiss Pediatric Oncology Group (SPOG)Public Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e38015 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefan Essig Nicolas X von der Weid Marie-Pierre F Strippoli Cornelia E Rebholz Gisela Michel Corina S Rueegg Felix K Niggli Claudia E Kuehni Swiss Pediatric Oncology Group (SPOG) Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
description	<h4>Background</h4>Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compare HRQOL of ALL survivors with the general population, and of relapsed with non-relapsed ALL survivors.<h4>Methodology/principal findings</h4>As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976-2003 at age <16 years, survived ≥5 years, and were currently aged ≥16 years. HRQOL was assessed with the Short Form-36 (SF-36), which measures four aspects of physical health and four aspects of mental health. A score of 50 corresponded to the mean of a healthy reference population. We analyzed data from 457 ALL survivors (response: 79%). Sixty-one survivors had suffered a relapse. Compared to the general population, ALL survivors reported similar or higher HRQOL scores on all scales. Survivors with a relapse scored lower in general health perceptions (51.6) compared to those without (55.8;p=0.005), but after adjusting for self-reported late effects, this difference disappeared.<h4>Conclusion/significance</h4>Compared to population norms, ALL survivors reported good HRQOL, even after a relapse. However, relapsed ALL survivors reported poorer general health than non-relapsed. Therefore, we encourage specialists to screen for poor general health in survivors after a relapse and, when appropriate, specifically seek and treat underlying late effects. This will help to improve patients' HRQOL.
format	article
author	Stefan Essig Nicolas X von der Weid Marie-Pierre F Strippoli Cornelia E Rebholz Gisela Michel Corina S Rueegg Felix K Niggli Claudia E Kuehni Swiss Pediatric Oncology Group (SPOG)
author_facet	Stefan Essig Nicolas X von der Weid Marie-Pierre F Strippoli Cornelia E Rebholz Gisela Michel Corina S Rueegg Felix K Niggli Claudia E Kuehni Swiss Pediatric Oncology Group (SPOG)
author_sort	Stefan Essig
title	Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
title_short	Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
title_full	Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
title_fullStr	Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
title_full_unstemmed	Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
title_sort	health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/17a27f2e3977434d85a86074d6c30f12
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Health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia.

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