Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study

Background: The mechanisms of periimplantitis are mostly based on biofilm-induced inflammatory lesions around dental implants. However, the host reaction, reflected by the intensity of the inflammatory response to bacterial products, is crucial for peri-implant bone destruction. The aim of this pilo...

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Autores principales:	Sergiu Drafta, Dragos Mihai Guita, Corina Marilena Cristache, Irina Adriana Beuran, Mihai Burlibasa, Alexandru Eugen Petre, Liliana Burlibasa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	salivary biomarker marginal bone loss periimplantitis total antioxidant status Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/17a34487d1a1417ba2368755c5393e41
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spelling	oai:doaj.org-article:17a34487d1a1417ba2368755c5393e412021-11-25T16:42:54ZCould Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study10.3390/app1122110122076-3417https://doaj.org/article/17a34487d1a1417ba2368755c5393e412021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/11012https://doaj.org/toc/2076-3417Background: The mechanisms of periimplantitis are mostly based on biofilm-induced inflammatory lesions around dental implants. However, the host reaction, reflected by the intensity of the inflammatory response to bacterial products, is crucial for peri-implant bone destruction. The aim of this pilot study was to measure total antioxidant status (TAS), the amount of IL-6, IL-8 and TNF-α (tumor necrosis factor), salivary lactate dehydrogenase (LDH) levels and the correlation with one-year peri-implant bone loss. Methods: Seven consecutive patients (Group 1), with the presence of at least one prior inserted dental implant, and three healthy individuals, fully dentate (Group 0), were enrolled. IL-6, IL-8, TNF-α, TAS and LDH were determined in saliva of both groups. Peri-implant marginal bone loss (MBL) at one year compared to baseline was evaluated for Group 1. Results: A statistically significant positive correlation was found in Group 1 between MBL and the IL-8 (<i>p</i> = 0.033) and a strong negative correlation between MBL and TAS (<i>p</i> = 0.002), but no statistically significant differences of the assessed parameters were found between the two groups. Conclusions: In the limits of the present preliminary study, salivary TAS and proinflammatory cytokines could be associated with the risk of peri-implant bone loss over time.Sergiu DraftaDragos Mihai GuitaCorina Marilena CristacheIrina Adriana BeuranMihai BurlibasaAlexandru Eugen PetreLiliana BurlibasaMDPI AGarticlesalivary biomarkermarginal bone lossperiimplantitistotal antioxidant statusTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 11012, p 11012 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	salivary biomarker marginal bone loss periimplantitis total antioxidant status Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	salivary biomarker marginal bone loss periimplantitis total antioxidant status Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Sergiu Drafta Dragos Mihai Guita Corina Marilena Cristache Irina Adriana Beuran Mihai Burlibasa Alexandru Eugen Petre Liliana Burlibasa Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study
description	Background: The mechanisms of periimplantitis are mostly based on biofilm-induced inflammatory lesions around dental implants. However, the host reaction, reflected by the intensity of the inflammatory response to bacterial products, is crucial for peri-implant bone destruction. The aim of this pilot study was to measure total antioxidant status (TAS), the amount of IL-6, IL-8 and TNF-α (tumor necrosis factor), salivary lactate dehydrogenase (LDH) levels and the correlation with one-year peri-implant bone loss. Methods: Seven consecutive patients (Group 1), with the presence of at least one prior inserted dental implant, and three healthy individuals, fully dentate (Group 0), were enrolled. IL-6, IL-8, TNF-α, TAS and LDH were determined in saliva of both groups. Peri-implant marginal bone loss (MBL) at one year compared to baseline was evaluated for Group 1. Results: A statistically significant positive correlation was found in Group 1 between MBL and the IL-8 (<i>p</i> = 0.033) and a strong negative correlation between MBL and TAS (<i>p</i> = 0.002), but no statistically significant differences of the assessed parameters were found between the two groups. Conclusions: In the limits of the present preliminary study, salivary TAS and proinflammatory cytokines could be associated with the risk of peri-implant bone loss over time.
format	article
author	Sergiu Drafta Dragos Mihai Guita Corina Marilena Cristache Irina Adriana Beuran Mihai Burlibasa Alexandru Eugen Petre Liliana Burlibasa
author_facet	Sergiu Drafta Dragos Mihai Guita Corina Marilena Cristache Irina Adriana Beuran Mihai Burlibasa Alexandru Eugen Petre Liliana Burlibasa
author_sort	Sergiu Drafta
title	Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study
title_short	Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study
title_full	Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study
title_fullStr	Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study
title_full_unstemmed	Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study
title_sort	could pro-inflammatory cytokines levels il-6, il-8, tnfα, total antioxidant status and lactate dehydrogenase be associated with peri-implant bone loss? a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/17a34487d1a1417ba2368755c5393e41
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Could Pro-Inflammatory Cytokines Levels IL-6, IL-8, TNFα, Total Antioxidant Status and Lactate Dehydrogenase Be Associated with Peri-Implant Bone Loss? A Pilot Study

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