Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

Protection from neutralization-resistant SIV variants is particularly difficult to achieve by vaccination. Here, Keeleet al. use sieve analysis and show that TRIM5a restrictive rhesus monkeys are protected from neutralization-resistant SIVsmE660 variants by an adenovirus prime, env protein boost vac...

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Autores principales:	Brandon F. Keele, Wenjun Li, Erica N. Borducchi, Joseph P. Nkolola, Peter Abbink, Bing Chen, Michael S. Seaman, Dan H. Barouch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17a396a6246b4ac0bac837740e4708bf
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spelling	oai:doaj.org-article:17a396a6246b4ac0bac837740e4708bf2021-12-02T14:42:44ZAdenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys10.1038/ncomms157402041-1723https://doaj.org/article/17a396a6246b4ac0bac837740e4708bf2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15740https://doaj.org/toc/2041-1723Protection from neutralization-resistant SIV variants is particularly difficult to achieve by vaccination. Here, Keeleet al. use sieve analysis and show that TRIM5a restrictive rhesus monkeys are protected from neutralization-resistant SIVsmE660 variants by an adenovirus prime, env protein boost vaccine.Brandon F. KeeleWenjun LiErica N. BorducchiJoseph P. NkololaPeter AbbinkBing ChenMichael S. SeamanDan H. BarouchNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brandon F. Keele Wenjun Li Erica N. Borducchi Joseph P. Nkolola Peter Abbink Bing Chen Michael S. Seaman Dan H. Barouch Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
description	Protection from neutralization-resistant SIV variants is particularly difficult to achieve by vaccination. Here, Keeleet al. use sieve analysis and show that TRIM5a restrictive rhesus monkeys are protected from neutralization-resistant SIVsmE660 variants by an adenovirus prime, env protein boost vaccine.
format	article
author	Brandon F. Keele Wenjun Li Erica N. Borducchi Joseph P. Nkolola Peter Abbink Bing Chen Michael S. Seaman Dan H. Barouch
author_facet	Brandon F. Keele Wenjun Li Erica N. Borducchi Joseph P. Nkolola Peter Abbink Bing Chen Michael S. Seaman Dan H. Barouch
author_sort	Brandon F. Keele
title	Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
title_short	Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
title_full	Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
title_fullStr	Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
title_full_unstemmed	Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys
title_sort	adenovirus prime, env protein boost vaccine protects against neutralization-resistant sivsme660 variants in rhesus monkeys
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/17a396a6246b4ac0bac837740e4708bf
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Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

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