Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

Protection from neutralization-resistant SIV variants is particularly difficult to achieve by vaccination. Here, Keeleet al. use sieve analysis and show that TRIM5a restrictive rhesus monkeys are protected from neutralization-resistant SIVsmE660 variants by an adenovirus prime, env protein boost vac...

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Autores principales: Brandon F. Keele, Wenjun Li, Erica N. Borducchi, Joseph P. Nkolola, Peter Abbink, Bing Chen, Michael S. Seaman, Dan H. Barouch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/17a396a6246b4ac0bac837740e4708bf
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