Anterior lamina cribrosa surface depth in healthy Saudi females

Amira El-Agamy,1,2,* Fayrouz Oteaf,1,* Mohamed Berika3,4 1Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Rehabilitation Science Dep...

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Autores principales:	El-Agamy A, Oteaf F, Berika M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Optical Coherence Tomography and Anterior Lamina Cribrosa Surface Depth Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/17a4be53ec5649cd99b657d7c5330eb7
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spelling	oai:doaj.org-article:17a4be53ec5649cd99b657d7c5330eb72021-12-02T06:09:20ZAnterior lamina cribrosa surface depth in healthy Saudi females1177-5483https://doaj.org/article/17a4be53ec5649cd99b657d7c5330eb72017-06-01T00:00:00Zhttps://www.dovepress.com/anterior-lamina-cribrosa-surface-depth-in-healthy-saudi-females-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Amira El-Agamy,1,2,* Fayrouz Oteaf,1,* Mohamed Berika3,4 1Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Rehabilitation Science Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 4Anatomy Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt *These authors contributed equally to this work Purpose: This study was conducted to determine normative profile of anterior lamina cribrosa surface depth (ALCSD) in healthy Saudi females using Topcon Three-Dimensional (3D) Optical Coherence Tomography (OCT) 2000 – Spectral Domain (SD-OCT). In addition, the correlation between ALCSD and other clinical factors such as age, refractive error, intraocular pressure (IOP), central corneal thickness, anterior chamber depth, axial length, retinal nerve fiber layer thickness, and disk area was also assessed.Design: This study was a prospective, nonrandomized, cross-sectional, observational, and quantitative study.Methods: This study included 191 eyes of 191 healthy Saudi females from the College of Applied Medical Sciences of King Saud University. Stereoscopic disk photographs were reconstructed using Topcon 3D OCT-2000 for all subjects. ALCSD was measured at three planes (superior, middle, and inferior) and defined as the distance from Bruch’s membrane opening level (reference line) to anterior lamina cribrosa surface. Average of ALCSD at all planes was defined as mean ALCSD of the eye. Correlation between ALCSD and all the clinical factors was performed by linear regression analysis. Paired t-test was performed in order to compare ALCSD at all planes.Results: In this study, the average ALCSD was 371.88±114.62 µm (range, 155–647.6 µm). Paired t-test showed a significant difference between superior and middle planes (P=0.004) and middle and inferior planes (P=0.013). Using the same test, no significant difference between superior and inferior planes (P=0.820) was observed. Generally, the largest ALCSD was in the middle plane. In addition, linear regression analysis showed no significant correlation between ALCSD and associated clinical factors.Conclusion: This work is the first to provide the normative profile of ALCSD in Saudi females using Topcon 3D OCT-2000. Further studies are recommended for males, different ethnic populations, high myopic eyes, and different age groups using advanced imaging techniques such as enhanced depth imaging OCT. Keywords: optical coherence tomography, anterior lamina cribrosa surface depthEl-Agamy AOteaf FBerika MDove Medical PressarticleOptical Coherence Tomography and Anterior Lamina Cribrosa Surface DepthOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1045-1050 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Optical Coherence Tomography and Anterior Lamina Cribrosa Surface Depth Ophthalmology RE1-994
spellingShingle	Optical Coherence Tomography and Anterior Lamina Cribrosa Surface Depth Ophthalmology RE1-994 El-Agamy A Oteaf F Berika M Anterior lamina cribrosa surface depth in healthy Saudi females
description	Amira El-Agamy,1,2,* Fayrouz Oteaf,1,* Mohamed Berika3,4 1Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Rehabilitation Science Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 4Anatomy Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt *These authors contributed equally to this work Purpose: This study was conducted to determine normative profile of anterior lamina cribrosa surface depth (ALCSD) in healthy Saudi females using Topcon Three-Dimensional (3D) Optical Coherence Tomography (OCT) 2000 – Spectral Domain (SD-OCT). In addition, the correlation between ALCSD and other clinical factors such as age, refractive error, intraocular pressure (IOP), central corneal thickness, anterior chamber depth, axial length, retinal nerve fiber layer thickness, and disk area was also assessed.Design: This study was a prospective, nonrandomized, cross-sectional, observational, and quantitative study.Methods: This study included 191 eyes of 191 healthy Saudi females from the College of Applied Medical Sciences of King Saud University. Stereoscopic disk photographs were reconstructed using Topcon 3D OCT-2000 for all subjects. ALCSD was measured at three planes (superior, middle, and inferior) and defined as the distance from Bruch’s membrane opening level (reference line) to anterior lamina cribrosa surface. Average of ALCSD at all planes was defined as mean ALCSD of the eye. Correlation between ALCSD and all the clinical factors was performed by linear regression analysis. Paired t-test was performed in order to compare ALCSD at all planes.Results: In this study, the average ALCSD was 371.88±114.62 µm (range, 155–647.6 µm). Paired t-test showed a significant difference between superior and middle planes (P=0.004) and middle and inferior planes (P=0.013). Using the same test, no significant difference between superior and inferior planes (P=0.820) was observed. Generally, the largest ALCSD was in the middle plane. In addition, linear regression analysis showed no significant correlation between ALCSD and associated clinical factors.Conclusion: This work is the first to provide the normative profile of ALCSD in Saudi females using Topcon 3D OCT-2000. Further studies are recommended for males, different ethnic populations, high myopic eyes, and different age groups using advanced imaging techniques such as enhanced depth imaging OCT. Keywords: optical coherence tomography, anterior lamina cribrosa surface depth
format	article
author	El-Agamy A Oteaf F Berika M
author_facet	El-Agamy A Oteaf F Berika M
author_sort	El-Agamy A
title	Anterior lamina cribrosa surface depth in healthy Saudi females
title_short	Anterior lamina cribrosa surface depth in healthy Saudi females
title_full	Anterior lamina cribrosa surface depth in healthy Saudi females
title_fullStr	Anterior lamina cribrosa surface depth in healthy Saudi females
title_full_unstemmed	Anterior lamina cribrosa surface depth in healthy Saudi females
title_sort	anterior lamina cribrosa surface depth in healthy saudi females
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/17a4be53ec5649cd99b657d7c5330eb7
work_keys_str_mv	AT elagamya anteriorlaminacribrosasurfacedepthinhealthysaudifemales AT oteaff anteriorlaminacribrosasurfacedepthinhealthysaudifemales AT berikam anteriorlaminacribrosasurfacedepthinhealthysaudifemales
_version_	1718400037455659008

Anterior lamina cribrosa surface depth in healthy Saudi females

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