Initiating polyketide biosynthesis by on-line methyl esterification

Aurantinins are polyketides with unusual connectivities and broad antibacterial activity. Here the authors show the biosynthesis of aurantinins, which proceeds via an on-line methyl esterification at the terminus that enables the iterative chain elongations prior to condensation and cyclization.

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Autores principales:	Pengwei Li, Meng Chen, Wei Tang, Zhengyan Guo, Yuwei Zhang, Min Wang, Geoff P. Horsman, Jin Zhong, Zhaoxin Lu, Yihua Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17a9762c282e428bbcf7cc9a94dae5c5
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spelling	oai:doaj.org-article:17a9762c282e428bbcf7cc9a94dae5c52021-12-02T16:26:40ZInitiating polyketide biosynthesis by on-line methyl esterification10.1038/s41467-021-24846-72041-1723https://doaj.org/article/17a9762c282e428bbcf7cc9a94dae5c52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24846-7https://doaj.org/toc/2041-1723Aurantinins are polyketides with unusual connectivities and broad antibacterial activity. Here the authors show the biosynthesis of aurantinins, which proceeds via an on-line methyl esterification at the terminus that enables the iterative chain elongations prior to condensation and cyclization.Pengwei LiMeng ChenWei TangZhengyan GuoYuwei ZhangMin WangGeoff P. HorsmanJin ZhongZhaoxin LuYihua ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pengwei Li Meng Chen Wei Tang Zhengyan Guo Yuwei Zhang Min Wang Geoff P. Horsman Jin Zhong Zhaoxin Lu Yihua Chen Initiating polyketide biosynthesis by on-line methyl esterification
description	Aurantinins are polyketides with unusual connectivities and broad antibacterial activity. Here the authors show the biosynthesis of aurantinins, which proceeds via an on-line methyl esterification at the terminus that enables the iterative chain elongations prior to condensation and cyclization.
format	article
author	Pengwei Li Meng Chen Wei Tang Zhengyan Guo Yuwei Zhang Min Wang Geoff P. Horsman Jin Zhong Zhaoxin Lu Yihua Chen
author_facet	Pengwei Li Meng Chen Wei Tang Zhengyan Guo Yuwei Zhang Min Wang Geoff P. Horsman Jin Zhong Zhaoxin Lu Yihua Chen
author_sort	Pengwei Li
title	Initiating polyketide biosynthesis by on-line methyl esterification
title_short	Initiating polyketide biosynthesis by on-line methyl esterification
title_full	Initiating polyketide biosynthesis by on-line methyl esterification
title_fullStr	Initiating polyketide biosynthesis by on-line methyl esterification
title_full_unstemmed	Initiating polyketide biosynthesis by on-line methyl esterification
title_sort	initiating polyketide biosynthesis by on-line methyl esterification
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17a9762c282e428bbcf7cc9a94dae5c5
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Initiating polyketide biosynthesis by on-line methyl esterification

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