Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

How cancer cells engage the microenvironment to establish metastasis is poorly understood. Here, the authors show that CXCR3-expressing breast cancer cells secrete IL-1 to induce a paracrine crosstalk with fibroblasts in the lung, which involves CXCL9/10 production and results in colonization of the...

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Autores principales:	Maren Pein, Jacob Insua-Rodríguez, Tsunaki Hongu, Angela Riedel, Jasmin Meier, Lena Wiedmann, Kristin Decker, Marieke A. G. Essers, Hans-Peter Sinn, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss, Andreas Trumpp, Thordur Oskarsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17acb7c31f7941f0959b5034c6bfd4bc
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spelling	oai:doaj.org-article:17acb7c31f7941f0959b5034c6bfd4bc2021-12-02T15:39:14ZMetastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs10.1038/s41467-020-15188-x2041-1723https://doaj.org/article/17acb7c31f7941f0959b5034c6bfd4bc2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15188-xhttps://doaj.org/toc/2041-1723How cancer cells engage the microenvironment to establish metastasis is poorly understood. Here, the authors show that CXCR3-expressing breast cancer cells secrete IL-1 to induce a paracrine crosstalk with fibroblasts in the lung, which involves CXCL9/10 production and results in colonization of the lung.Maren PeinJacob Insua-RodríguezTsunaki HonguAngela RiedelJasmin MeierLena WiedmannKristin DeckerMarieke A. G. EssersHans-Peter SinnSaskia SpaichMarc SütterlinAndreas SchneeweissAndreas TrumppThordur OskarssonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maren Pein Jacob Insua-Rodríguez Tsunaki Hongu Angela Riedel Jasmin Meier Lena Wiedmann Kristin Decker Marieke A. G. Essers Hans-Peter Sinn Saskia Spaich Marc Sütterlin Andreas Schneeweiss Andreas Trumpp Thordur Oskarsson Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
description	How cancer cells engage the microenvironment to establish metastasis is poorly understood. Here, the authors show that CXCR3-expressing breast cancer cells secrete IL-1 to induce a paracrine crosstalk with fibroblasts in the lung, which involves CXCL9/10 production and results in colonization of the lung.
format	article
author	Maren Pein Jacob Insua-Rodríguez Tsunaki Hongu Angela Riedel Jasmin Meier Lena Wiedmann Kristin Decker Marieke A. G. Essers Hans-Peter Sinn Saskia Spaich Marc Sütterlin Andreas Schneeweiss Andreas Trumpp Thordur Oskarsson
author_facet	Maren Pein Jacob Insua-Rodríguez Tsunaki Hongu Angela Riedel Jasmin Meier Lena Wiedmann Kristin Decker Marieke A. G. Essers Hans-Peter Sinn Saskia Spaich Marc Sütterlin Andreas Schneeweiss Andreas Trumpp Thordur Oskarsson
author_sort	Maren Pein
title	Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
title_short	Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
title_full	Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
title_fullStr	Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
title_full_unstemmed	Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
title_sort	metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/17acb7c31f7941f0959b5034c6bfd4bc
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Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

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