Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
How cancer cells engage the microenvironment to establish metastasis is poorly understood. Here, the authors show that CXCR3-expressing breast cancer cells secrete IL-1 to induce a paracrine crosstalk with fibroblasts in the lung, which involves CXCL9/10 production and results in colonization of the...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2020
|
| Subjects: | |
| Online Access: | https://doaj.org/article/17acb7c31f7941f0959b5034c6bfd4bc |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|