Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like receptor signaling control the recruitment of CD14+Sirpα+...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, Dominik Filipp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17ae763d83f941499c6713566243bf8e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:17ae763d83f941499c6713566243bf8e
record_format	dspace
spelling	oai:doaj.org-article:17ae763d83f941499c6713566243bf8e2021-12-02T17:15:59ZToll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation10.1038/s41467-020-16081-32041-1723https://doaj.org/article/17ae763d83f941499c6713566243bf8e2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16081-3https://doaj.org/toc/2041-1723Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like receptor signaling control the recruitment of CD14+Sirpα+ DC population that is capable of inducing Treg for establishing tolerance.Matouš VobořilTomáš BrabecJan DobešIva ŠplíchalováJiří BřezinaAdéla ČepkováMartina DobešováAigerim AidarovaJan KubovčiakOksana TsyklauriOndřej ŠtěpánekVladimír BenešRadislav SedláčekLudger KleinMichal KolářDominik FilippNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matouš Vobořil Tomáš Brabec Jan Dobeš Iva Šplíchalová Jiří Březina Adéla Čepková Martina Dobešová Aigerim Aidarova Jan Kubovčiak Oksana Tsyklauri Ondřej Štěpánek Vladimír Beneš Radislav Sedláček Ludger Klein Michal Kolář Dominik Filipp Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
description	Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like receptor signaling control the recruitment of CD14+Sirpα+ DC population that is capable of inducing Treg for establishing tolerance.
format	article
author	Matouš Vobořil Tomáš Brabec Jan Dobeš Iva Šplíchalová Jiří Březina Adéla Čepková Martina Dobešová Aigerim Aidarova Jan Kubovčiak Oksana Tsyklauri Ondřej Štěpánek Vladimír Beneš Radislav Sedláček Ludger Klein Michal Kolář Dominik Filipp
author_facet	Matouš Vobořil Tomáš Brabec Jan Dobeš Iva Šplíchalová Jiří Březina Adéla Čepková Martina Dobešová Aigerim Aidarova Jan Kubovčiak Oksana Tsyklauri Ondřej Štěpánek Vladimír Beneš Radislav Sedláček Ludger Klein Michal Kolář Dominik Filipp
author_sort	Matouš Vobořil
title	Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
title_short	Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
title_full	Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
title_fullStr	Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
title_full_unstemmed	Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation
title_sort	toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and treg generation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/17ae763d83f941499c6713566243bf8e
work_keys_str_mv	AT matousvoboril tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT tomasbrabec tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT jandobes tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT ivasplichalova tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT jiribrezina tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT adelacepkova tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT martinadobesova tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT aigerimaidarova tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT jankubovciak tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT oksanatsyklauri tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT ondrejstepanek tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT vladimirbenes tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT radislavsedlacek tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT ludgerklein tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT michalkolar tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration AT dominikfilipp tolllikereceptorsignalinginthymicepitheliumcontrolsmonocytederiveddendriticcellrecruitmentandtreggeneration
_version_	1718381186735144960

Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

Ejemplares similares