Structure and evolution of the Fam20 kinases

Fam20 proteins are kinases that phosphorylate secreted proteins and proteoglycans. Here the authors present the crystal structures of the three Fam20 kinases and their complexes and give mechanistic insights into substrate recognition and the function and regulation of this kinase family.

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Detalles Bibliográficos
Autores principales:	Hui Zhang, Qinyu Zhu, Jixin Cui, Yuxin Wang, Mark J. Chen, Xing Guo, Vincent S. Tagliabracci, Jack E. Dixon, Junyu Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17af4b3603344b87a364eec04b64111a
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spelling	oai:doaj.org-article:17af4b3603344b87a364eec04b64111a2021-12-02T15:33:42ZStructure and evolution of the Fam20 kinases10.1038/s41467-018-03615-z2041-1723https://doaj.org/article/17af4b3603344b87a364eec04b64111a2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03615-zhttps://doaj.org/toc/2041-1723Fam20 proteins are kinases that phosphorylate secreted proteins and proteoglycans. Here the authors present the crystal structures of the three Fam20 kinases and their complexes and give mechanistic insights into substrate recognition and the function and regulation of this kinase family.Hui ZhangQinyu ZhuJixin CuiYuxin WangMark J. ChenXing GuoVincent S. TagliabracciJack E. DixonJunyu XiaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui Zhang Qinyu Zhu Jixin Cui Yuxin Wang Mark J. Chen Xing Guo Vincent S. Tagliabracci Jack E. Dixon Junyu Xiao Structure and evolution of the Fam20 kinases
description	Fam20 proteins are kinases that phosphorylate secreted proteins and proteoglycans. Here the authors present the crystal structures of the three Fam20 kinases and their complexes and give mechanistic insights into substrate recognition and the function and regulation of this kinase family.
format	article
author	Hui Zhang Qinyu Zhu Jixin Cui Yuxin Wang Mark J. Chen Xing Guo Vincent S. Tagliabracci Jack E. Dixon Junyu Xiao
author_facet	Hui Zhang Qinyu Zhu Jixin Cui Yuxin Wang Mark J. Chen Xing Guo Vincent S. Tagliabracci Jack E. Dixon Junyu Xiao
author_sort	Hui Zhang
title	Structure and evolution of the Fam20 kinases
title_short	Structure and evolution of the Fam20 kinases
title_full	Structure and evolution of the Fam20 kinases
title_fullStr	Structure and evolution of the Fam20 kinases
title_full_unstemmed	Structure and evolution of the Fam20 kinases
title_sort	structure and evolution of the fam20 kinases
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/17af4b3603344b87a364eec04b64111a
work_keys_str_mv	AT huizhang structureandevolutionofthefam20kinases AT qinyuzhu structureandevolutionofthefam20kinases AT jixincui structureandevolutionofthefam20kinases AT yuxinwang structureandevolutionofthefam20kinases AT markjchen structureandevolutionofthefam20kinases AT xingguo structureandevolutionofthefam20kinases AT vincentstagliabracci structureandevolutionofthefam20kinases AT jackedixon structureandevolutionofthefam20kinases AT junyuxiao structureandevolutionofthefam20kinases
_version_	1718387007269371904

Structure and evolution of the Fam20 kinases

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