IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy

Xudong Fu,1 Xinjun Wang,1 Shaolong Zhou,1 Yanyan Zhang2 1The Fifth Affiliated Hospital of Zhengzhou University, 2School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China Abstract: Despite advances in controlled drug delivery, drug delivery systems (DD...

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Autores principales:	Fu X, Wang X, Zhou S, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Controlled drug release magnetic targeting MRI combination therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/17b09f0385f8485fa603c3e4ef8a76fc
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spelling	oai:doaj.org-article:17b09f0385f8485fa603c3e4ef8a76fc2021-12-02T02:31:36ZIONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy1178-2013https://doaj.org/article/17b09f0385f8485fa603c3e4ef8a76fc2017-05-01T00:00:00Zhttps://www.dovepress.com/ionp-doped-nanoparticles-for-highly-effective-nir-controlled-drug-rele-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xudong Fu,1 Xinjun Wang,1 Shaolong Zhou,1 Yanyan Zhang2 1The Fifth Affiliated Hospital of Zhengzhou University, 2School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China Abstract: Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled “off–on” DDS with magnetic resonance imaging and magnetic targeting properties was developed using a hybrid nanoplatform (carbon nanotubes [CNTs]-iron oxide nanoparticle). Doxorubicin (DOX) and distearoyl-sn-glycero-3-phosphoethanolamine-PEG were adsorbed onto CNTs-iron oxide nanoparticle, and then to avoid the unexpected drug release during circulation, 1-myristyl alcohol was used to encapsulate the CNTs–drug complex. Herein, multifunctional DOX-loaded nanoparticles (NPs) with “off–on” state were developed. DOX-NPs showed an obvious “off–on” effect (temperature increase, drug release) controlled by near-infrared light in vitro and in vivo. In the in vivo and in vitro studies, DOX-NPs exhibited excellent magnetic resonance imaging ability, magnetic targeting property, high biosafety, and high antitumor combined therapeutic efficacy (hyperthermia combined with chemotherapy). These results highlight the great potential of DOX-NPs in the treatment of cancer. Keywords: controlled drug release, magnetic targeting, MRI, combination therapyFu XWang XZhou SZhang YDove Medical PressarticleControlled drug releasemagnetic targetingMRIcombination therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 3751-3766 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Controlled drug release magnetic targeting MRI combination therapy Medicine (General) R5-920
spellingShingle	Controlled drug release magnetic targeting MRI combination therapy Medicine (General) R5-920 Fu X Wang X Zhou S Zhang Y IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy
description	Xudong Fu,1 Xinjun Wang,1 Shaolong Zhou,1 Yanyan Zhang2 1The Fifth Affiliated Hospital of Zhengzhou University, 2School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, People’s Republic of China Abstract: Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled “off–on” DDS with magnetic resonance imaging and magnetic targeting properties was developed using a hybrid nanoplatform (carbon nanotubes [CNTs]-iron oxide nanoparticle). Doxorubicin (DOX) and distearoyl-sn-glycero-3-phosphoethanolamine-PEG were adsorbed onto CNTs-iron oxide nanoparticle, and then to avoid the unexpected drug release during circulation, 1-myristyl alcohol was used to encapsulate the CNTs–drug complex. Herein, multifunctional DOX-loaded nanoparticles (NPs) with “off–on” state were developed. DOX-NPs showed an obvious “off–on” effect (temperature increase, drug release) controlled by near-infrared light in vitro and in vivo. In the in vivo and in vitro studies, DOX-NPs exhibited excellent magnetic resonance imaging ability, magnetic targeting property, high biosafety, and high antitumor combined therapeutic efficacy (hyperthermia combined with chemotherapy). These results highlight the great potential of DOX-NPs in the treatment of cancer. Keywords: controlled drug release, magnetic targeting, MRI, combination therapy
format	article
author	Fu X Wang X Zhou S Zhang Y
author_facet	Fu X Wang X Zhou S Zhang Y
author_sort	Fu X
title	IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy
title_short	IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy
title_full	IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy
title_fullStr	IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy
title_full_unstemmed	IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy
title_sort	ionp-doped nanoparticles for highly effective nir-controlled drug release and combination tumor therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/17b09f0385f8485fa603c3e4ef8a76fc
work_keys_str_mv	AT fux ionpdopednanoparticlesforhighlyeffectivenircontrolleddrugreleaseandcombinationtumortherapy AT wangx ionpdopednanoparticlesforhighlyeffectivenircontrolleddrugreleaseandcombinationtumortherapy AT zhous ionpdopednanoparticlesforhighlyeffectivenircontrolleddrugreleaseandcombinationtumortherapy AT zhangy ionpdopednanoparticlesforhighlyeffectivenircontrolleddrugreleaseandcombinationtumortherapy
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IONP-doped nanoparticles for highly effective NIR-controlled drug release and combination tumor therapy

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