Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

BackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2) and its auxiliary proteins including c...

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Main Authors:	Bin Liu, Shane D. Walton, Hsiang‐Ting Ho, Andriy E. Belevych, Svetlana B. Tikunova, Ingrid Bonilla, Vikram Shettigar, Bjorn C. Knollmann, Silvia G. Priori, Pompeo Volpe, Przemysław B. Radwański, Jonathan P. Davis, Sándor Györke
Format:	article
Language:	EN
Published:	Wiley 2018
Subjects:	arrhythmia (mechanisms) calcium channel calcium signaling calmodulin gene therapy Diseases of the circulatory (Cardiovascular) system RC666-701
Online Access:	https://doaj.org/article/17b2d1203c6b4fb18ec412e87dd32e52
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Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

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