Impact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study
Little is known about the impact of giant cell arteritis (GCA) and its treatment on patient-reported physical, mental, and psychic quality of life (QoL). In this monocentric study, a questionnaire was sent to the 100 last patients diagnosed with GCA and followed-up in a single tertiary center. Their...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:17b3e4f1d6c948acb5773b1edf569b792021-11-10T06:58:57ZImpact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study2296-858X10.3389/fmed.2021.777310https://doaj.org/article/17b3e4f1d6c948acb5773b1edf569b792021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.777310/fullhttps://doaj.org/toc/2296-858XLittle is known about the impact of giant cell arteritis (GCA) and its treatment on patient-reported physical, mental, and psychic quality of life (QoL). In this monocentric study, a questionnaire was sent to the 100 last patients diagnosed with GCA and followed-up in a single tertiary center. Their physical, mental and psychic status were self-assessed via close-ended questions, the 12-item short form survey (SF-12) and the 15-item geriatric depression scale (GDS). We aimed to identify parameters that were significantly associated with moderate-to-severe disability in both physical and mental domains. Ninety patients were analyzable. Moderate to severe physical disability was found in 41 (46%) patients. In multivariate analysis, walking difficulties (OR, 95% CI 8.42 [2.98–26.82], p <0.0001), muscle mass and strength reduction (OR, 95% CI 4.38 [1.37–16.31], p = 0.01) and age >80 (OR, 95% CI 4.21 [1.44–13.61], p = 0.008) were independent findings associated with moderate to severe physical disability. Moderate to severe mental disability was found in 30 (33%) patients. In multivariate analysis, depressive mood (OR, 95% CI 11.05 [3.78–37.11], p < 0.0001), felt adverse events attributable to glucocorticoids (OR, 95% CI 10.54 [1.65–213.1], p = 0.01) and use of immune-suppressants (OR, 95% CI 3.50 [1.14–11.87], p = 0.03) were independent findings associated with moderate to severe mental disability. There was a statistically significant negative correlation between GDS and the physical and/or mental disability scores (GDS and PCS-12: r = −0.33, p = 0.0013; GDS and MCS-12: r = −0.36, p = 0.0005). In conclusion, this study identified via a self-assessment of patients with GCA some medical and modifiable findings that significantly affect their physical and mental quality of life. A better knowledge of these factors may help improve the care of GCA patients.Hubert de BoyssonHubert de BoyssonClivia BarakatAnael DumontAnael DumontJonathan BoutemyNicolas Martin SilvaGwénola MaignéAlexandre NguyenAlexandre NguyenAmandine LavergnePaul CastanSophie GallouAudrey SultanSamuel DeshayesSamuel DeshayesAchille AoubaAchille AoubaFrontiers Media S.A.articlegiant-cell arteritispatient report outcomeauto-questionnairequality of lifephysical disabilitiesmental disabilitiesMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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giant-cell arteritis patient report outcome auto-questionnaire quality of life physical disabilities mental disabilities Medicine (General) R5-920 |
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giant-cell arteritis patient report outcome auto-questionnaire quality of life physical disabilities mental disabilities Medicine (General) R5-920 Hubert de Boysson Hubert de Boysson Clivia Barakat Anael Dumont Anael Dumont Jonathan Boutemy Nicolas Martin Silva Gwénola Maigné Alexandre Nguyen Alexandre Nguyen Amandine Lavergne Paul Castan Sophie Gallou Audrey Sultan Samuel Deshayes Samuel Deshayes Achille Aouba Achille Aouba Impact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study |
| description |
Little is known about the impact of giant cell arteritis (GCA) and its treatment on patient-reported physical, mental, and psychic quality of life (QoL). In this monocentric study, a questionnaire was sent to the 100 last patients diagnosed with GCA and followed-up in a single tertiary center. Their physical, mental and psychic status were self-assessed via close-ended questions, the 12-item short form survey (SF-12) and the 15-item geriatric depression scale (GDS). We aimed to identify parameters that were significantly associated with moderate-to-severe disability in both physical and mental domains. Ninety patients were analyzable. Moderate to severe physical disability was found in 41 (46%) patients. In multivariate analysis, walking difficulties (OR, 95% CI 8.42 [2.98–26.82], p <0.0001), muscle mass and strength reduction (OR, 95% CI 4.38 [1.37–16.31], p = 0.01) and age >80 (OR, 95% CI 4.21 [1.44–13.61], p = 0.008) were independent findings associated with moderate to severe physical disability. Moderate to severe mental disability was found in 30 (33%) patients. In multivariate analysis, depressive mood (OR, 95% CI 11.05 [3.78–37.11], p < 0.0001), felt adverse events attributable to glucocorticoids (OR, 95% CI 10.54 [1.65–213.1], p = 0.01) and use of immune-suppressants (OR, 95% CI 3.50 [1.14–11.87], p = 0.03) were independent findings associated with moderate to severe mental disability. There was a statistically significant negative correlation between GDS and the physical and/or mental disability scores (GDS and PCS-12: r = −0.33, p = 0.0013; GDS and MCS-12: r = −0.36, p = 0.0005). In conclusion, this study identified via a self-assessment of patients with GCA some medical and modifiable findings that significantly affect their physical and mental quality of life. A better knowledge of these factors may help improve the care of GCA patients. |
| format |
article |
| author |
Hubert de Boysson Hubert de Boysson Clivia Barakat Anael Dumont Anael Dumont Jonathan Boutemy Nicolas Martin Silva Gwénola Maigné Alexandre Nguyen Alexandre Nguyen Amandine Lavergne Paul Castan Sophie Gallou Audrey Sultan Samuel Deshayes Samuel Deshayes Achille Aouba Achille Aouba |
| author_facet |
Hubert de Boysson Hubert de Boysson Clivia Barakat Anael Dumont Anael Dumont Jonathan Boutemy Nicolas Martin Silva Gwénola Maigné Alexandre Nguyen Alexandre Nguyen Amandine Lavergne Paul Castan Sophie Gallou Audrey Sultan Samuel Deshayes Samuel Deshayes Achille Aouba Achille Aouba |
| author_sort |
Hubert de Boysson |
| title |
Impact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study |
| title_short |
Impact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study |
| title_full |
Impact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study |
| title_fullStr |
Impact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study |
| title_full_unstemmed |
Impact of Giant Cell Arteritis and Its Treatment on the Patient's Quality of Life: A Single-Center Self-Assessment Study |
| title_sort |
impact of giant cell arteritis and its treatment on the patient's quality of life: a single-center self-assessment study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/17b3e4f1d6c948acb5773b1edf569b79 |
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