Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

Abstract Enabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A p...

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Autores principales:	Ata Chizari, Mirjam J. Schaap, Tom Knop, Yoeri E. Boink, Marieke M. B. Seyger, Wiendelt Steenbergen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/17b3ed87cb9f49e18dafb2c33515d3b1
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spelling	oai:doaj.org-article:17b3ed87cb9f49e18dafb2c33515d3b12021-12-02T15:10:46ZHandheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions10.1038/s41598-021-96218-62045-2322https://doaj.org/article/17b3ed87cb9f49e18dafb2c33515d3b12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96218-6https://doaj.org/toc/2045-2322Abstract Enabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A pipeline is introduced to process, analyze and compare data of 11 measurement pairs (mounted-handheld LSCI modes) operated on 5 patients and various skin locations. The on-surface speeds (i.e. speed of light beam movements on the surface) are quantified employing mean separation (MS) segmentation and enhanced correlation coefficient maximization (ECC). The average on-surface speeds are found to be 8.5 times greater in handheld mode compared to mounted mode. Frame alignment sharpens temporally averaged perfusion maps, especially in the handheld case. The results show that after proper post-processing, the handheld measurements are in agreement with the corresponding mounted measurements on a visual basis. The absolute movement-induced difference between mounted-handheld pairs after the background correction is $$16.4\pm 9.3~\%$$ 16.4 ± 9.3 % (mean ± std, $$n=11$$ n = 11 ), with an absolute median difference of $$23.8\%$$ 23.8 % . Realization of handheld LSCI facilitates measurements on a wide range of skin areas bringing more convenience for both patients and medical staff.Ata ChizariMirjam J. SchaapTom KnopYoeri E. BoinkMarieke M. B. SeygerWiendelt SteenbergenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ata Chizari Mirjam J. Schaap Tom Knop Yoeri E. Boink Marieke M. B. Seyger Wiendelt Steenbergen Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions
description	Abstract Enabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A pipeline is introduced to process, analyze and compare data of 11 measurement pairs (mounted-handheld LSCI modes) operated on 5 patients and various skin locations. The on-surface speeds (i.e. speed of light beam movements on the surface) are quantified employing mean separation (MS) segmentation and enhanced correlation coefficient maximization (ECC). The average on-surface speeds are found to be 8.5 times greater in handheld mode compared to mounted mode. Frame alignment sharpens temporally averaged perfusion maps, especially in the handheld case. The results show that after proper post-processing, the handheld measurements are in agreement with the corresponding mounted measurements on a visual basis. The absolute movement-induced difference between mounted-handheld pairs after the background correction is $$16.4\pm 9.3~\%$$ 16.4 ± 9.3 % (mean ± std, $$n=11$$ n = 11 ), with an absolute median difference of $$23.8\%$$ 23.8 % . Realization of handheld LSCI facilitates measurements on a wide range of skin areas bringing more convenience for both patients and medical staff.
format	article
author	Ata Chizari Mirjam J. Schaap Tom Knop Yoeri E. Boink Marieke M. B. Seyger Wiendelt Steenbergen
author_facet	Ata Chizari Mirjam J. Schaap Tom Knop Yoeri E. Boink Marieke M. B. Seyger Wiendelt Steenbergen
author_sort	Ata Chizari
title	Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions
title_short	Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions
title_full	Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions
title_fullStr	Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions
title_full_unstemmed	Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions
title_sort	handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/17b3ed87cb9f49e18dafb2c33515d3b1
work_keys_str_mv	AT atachizari handheldversusmountedlaserspecklecontrastperfusionimagingdemonstratedinpsoriasislesions AT mirjamjschaap handheldversusmountedlaserspecklecontrastperfusionimagingdemonstratedinpsoriasislesions AT tomknop handheldversusmountedlaserspecklecontrastperfusionimagingdemonstratedinpsoriasislesions AT yoerieboink handheldversusmountedlaserspecklecontrastperfusionimagingdemonstratedinpsoriasislesions AT mariekembseyger handheldversusmountedlaserspecklecontrastperfusionimagingdemonstratedinpsoriasislesions AT wiendeltsteenbergen handheldversusmountedlaserspecklecontrastperfusionimagingdemonstratedinpsoriasislesions
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Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

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