FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

FDNC4 is a poorly characterized homologue of FNDC5/irisin, a myokine induced by exercise. Here the authors show that FDNC4 increases macrophage survival in growth factor deprivation, inhibits phagocytosis and transcriptional responses to M1 and M2 polarizing stimuli, and protects mice from DSS-induc...

Full description

Saved in:
Bibliographic Details
Main Authors: Madeleen Bosma, Marco Gerling, Jenny Pasto, Anastasia Georgiadi, Evan Graham, Olga Shilkova, Yasunori Iwata, Sven Almer, Jan Söderman, Rune Toftgård, Fredrik Wermeling, Elisabeth Almer Boström, Pontus Almer Boström
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/17b58db1f2fe4257b1e5e50f6ef241f8
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:FDNC4 is a poorly characterized homologue of FNDC5/irisin, a myokine induced by exercise. Here the authors show that FDNC4 increases macrophage survival in growth factor deprivation, inhibits phagocytosis and transcriptional responses to M1 and M2 polarizing stimuli, and protects mice from DSS-induced colitis.

Similar Items