FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

FDNC4 is a poorly characterized homologue of FNDC5/irisin, a myokine induced by exercise. Here the authors show that FDNC4 increases macrophage survival in growth factor deprivation, inhibits phagocytosis and transcriptional responses to M1 and M2 polarizing stimuli, and protects mice from DSS-induc...

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Autores principales:	Madeleen Bosma, Marco Gerling, Jenny Pasto, Anastasia Georgiadi, Evan Graham, Olga Shilkova, Yasunori Iwata, Sven Almer, Jan Söderman, Rune Toftgård, Fredrik Wermeling, Elisabeth Almer Boström, Pontus Almer Boström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/17b58db1f2fe4257b1e5e50f6ef241f8
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spelling	oai:doaj.org-article:17b58db1f2fe4257b1e5e50f6ef241f82021-12-02T15:34:50ZFNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice10.1038/ncomms113142041-1723https://doaj.org/article/17b58db1f2fe4257b1e5e50f6ef241f82016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11314https://doaj.org/toc/2041-1723FDNC4 is a poorly characterized homologue of FNDC5/irisin, a myokine induced by exercise. Here the authors show that FDNC4 increases macrophage survival in growth factor deprivation, inhibits phagocytosis and transcriptional responses to M1 and M2 polarizing stimuli, and protects mice from DSS-induced colitis.Madeleen BosmaMarco GerlingJenny PastoAnastasia GeorgiadiEvan GrahamOlga ShilkovaYasunori IwataSven AlmerJan SödermanRune ToftgårdFredrik WermelingElisabeth Almer BoströmPontus Almer BoströmNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Madeleen Bosma Marco Gerling Jenny Pasto Anastasia Georgiadi Evan Graham Olga Shilkova Yasunori Iwata Sven Almer Jan Söderman Rune Toftgård Fredrik Wermeling Elisabeth Almer Boström Pontus Almer Boström FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
description	FDNC4 is a poorly characterized homologue of FNDC5/irisin, a myokine induced by exercise. Here the authors show that FDNC4 increases macrophage survival in growth factor deprivation, inhibits phagocytosis and transcriptional responses to M1 and M2 polarizing stimuli, and protects mice from DSS-induced colitis.
format	article
author	Madeleen Bosma Marco Gerling Jenny Pasto Anastasia Georgiadi Evan Graham Olga Shilkova Yasunori Iwata Sven Almer Jan Söderman Rune Toftgård Fredrik Wermeling Elisabeth Almer Boström Pontus Almer Boström
author_facet	Madeleen Bosma Marco Gerling Jenny Pasto Anastasia Georgiadi Evan Graham Olga Shilkova Yasunori Iwata Sven Almer Jan Söderman Rune Toftgård Fredrik Wermeling Elisabeth Almer Boström Pontus Almer Boström
author_sort	Madeleen Bosma
title	FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
title_short	FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
title_full	FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
title_fullStr	FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
title_full_unstemmed	FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
title_sort	fndc4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/17b58db1f2fe4257b1e5e50f6ef241f8
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FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice

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