Plugging Small RNAs into the Network

ABSTRACT Small RNAs (sRNAs) have been discovered in every bacterium examined and have been shown to play important roles in the regulation of a diverse range of behaviors, from metabolism to infection. However, despite a wide range of available techniques for discovering and validating sRNA regulato...

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Autor principal:	Lars Barquist
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	network inference ncRNA sRNA Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/17b7b2dbb6a64b00946cc8a93128789b
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spelling	oai:doaj.org-article:17b7b2dbb6a64b00946cc8a93128789b2021-12-02T19:46:20ZPlugging Small RNAs into the Network10.1128/mSystems.00422-202379-5077https://doaj.org/article/17b7b2dbb6a64b00946cc8a93128789b2020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00422-20https://doaj.org/toc/2379-5077ABSTRACT Small RNAs (sRNAs) have been discovered in every bacterium examined and have been shown to play important roles in the regulation of a diverse range of behaviors, from metabolism to infection. However, despite a wide range of available techniques for discovering and validating sRNA regulatory interactions, only a minority of these molecules have been well characterized. In part, this is due to the nature of posttranscriptional regulation: the activity of an sRNA depends on the state of the transcriptome as a whole, so characterization is best carried out under the conditions in which it is naturally active. In this issue of mSystems, Arrieta-Ortiz and colleagues (M. L. Arrieta-Ortiz, C. Hafemeister, B. Shuster, N. S. Baliga, et al., mSystems 5:e00057-20, 2020, https://doi.org/10.1128/mSystems.00057-20) present a network inference approach based on estimating sRNA activity across transcriptomic compendia. This shows promise not only for identifying new sRNA regulatory interactions but also for pinpointing the conditions in which these interactions occur, providing a new avenue toward functional characterization of sRNAs.Lars BarquistAmerican Society for Microbiologyarticlenetwork inferencencRNAsRNAMicrobiologyQR1-502ENmSystems, Vol 5, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	network inference ncRNA sRNA Microbiology QR1-502
spellingShingle	network inference ncRNA sRNA Microbiology QR1-502 Lars Barquist Plugging Small RNAs into the Network
description	ABSTRACT Small RNAs (sRNAs) have been discovered in every bacterium examined and have been shown to play important roles in the regulation of a diverse range of behaviors, from metabolism to infection. However, despite a wide range of available techniques for discovering and validating sRNA regulatory interactions, only a minority of these molecules have been well characterized. In part, this is due to the nature of posttranscriptional regulation: the activity of an sRNA depends on the state of the transcriptome as a whole, so characterization is best carried out under the conditions in which it is naturally active. In this issue of mSystems, Arrieta-Ortiz and colleagues (M. L. Arrieta-Ortiz, C. Hafemeister, B. Shuster, N. S. Baliga, et al., mSystems 5:e00057-20, 2020, https://doi.org/10.1128/mSystems.00057-20) present a network inference approach based on estimating sRNA activity across transcriptomic compendia. This shows promise not only for identifying new sRNA regulatory interactions but also for pinpointing the conditions in which these interactions occur, providing a new avenue toward functional characterization of sRNAs.
format	article
author	Lars Barquist
author_facet	Lars Barquist
author_sort	Lars Barquist
title	Plugging Small RNAs into the Network
title_short	Plugging Small RNAs into the Network
title_full	Plugging Small RNAs into the Network
title_fullStr	Plugging Small RNAs into the Network
title_full_unstemmed	Plugging Small RNAs into the Network
title_sort	plugging small rnas into the network
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/17b7b2dbb6a64b00946cc8a93128789b
work_keys_str_mv	AT larsbarquist pluggingsmallrnasintothenetwork
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Plugging Small RNAs into the Network

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